Human mesenchymal stem cells (MSCs) for treatment towards immune- and inflammation-mediated diseases: review of current clinical trials

被引：141
作者：
Wang, Li-Tzu [1 ,2 ]
Ting, Chiao-Hsuan [1 ]
Yen, Men-Luh [3 ,4 ]
Liu, Ko-Jiunn [5 ]
Sytwu, Huey-Kang [2 ,6 ]
Wu, Kenneth K. [1 ,7 ]
Yen, B. Linju [1 ]
机构：
[1] Natl Hlth Res Inst, Inst Cellular & Syst Med, Regenerat Med Res Grp, 35 Keyan Rd, Zhunan 35053, Taiwan
[2] NDMC, Grad Inst Life Sci, Taipei, Taiwan
[3] Natl Taiwan Univ Hosp, Dept Ob Gyn, Taipei, Taiwan
[4] Natl Taiwan Univ, Coll Med, Taipei, Taiwan
[5] NHRI, Natl Inst Canc Res, Tainan, Taiwan
[6] NDMC, Grad Inst Microbiol & Immunol, Taipei, Taiwan
[7] China Med Coll, Grad Inst Basic Med Sci, Taichung, Taiwan
来源：
JOURNAL OF BIOMEDICAL SCIENCE | 2016年 / 23卷
关键词：
Mesenchymal stem cells; Human; Immunomodulation; Inflammation; Clinical trials; Autoimmune disease; Organ transplantation and rejection; Stem cell therapy; VERSUS-HOST-DISEASE; ACUTE LUNG INJURY; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; ALLERGIC AIRWAY INFLAMMATION; DSS-INDUCED COLITIS; STROMAL CELLS; MOUSE MODEL; CROHNS-DISEASE; IN-VITRO; LYMPHOCYTE-PROLIFERATION;
D O I：
10.1186/s12929-016-0289-5
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Human mesenchymal stem cells (MSCs) are multilineage somatic progenitor/stem cells that have been shown to possess immunomodulatory properties in recent years. Initially met with much skepticism, MSC immunomodulation has now been well reproduced across tissue sources and species to be clinically relevant. This has opened up the use of these versatile cells for application as 3rd party/allogeneic use in cell replacement/tissue regeneration, as well as for immune-and inflammation-mediated disease entities. Most surprisingly, use of MSCs for in immune-/inflammation-mediated diseases appears to yield more efficacy than for regenerative medicine, since engraftment of the exogenous cell does not appear necessary. In this review, we focus on this non-traditional clinical use of a tissue-specific stem cell, and highlight important findings and trends in this exciting area of stem cell therapy.
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页码：1 / 13
页数：13
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共 148 条
  • [61] Treatment of Graft versus Host Disease with Mesenchymal Stromal Cells: A Phase I Study on 40 Adult and Pediatric Patients
    Introna, Martino
    Lucchini, Giovanna
    Dander, Erica
    Galimberti, Stefania
    Rovelli, Attilio
    Balduzzi, Adriana
    Longoni, Daniela
    Pavan, Fabio
    Masciocchi, Francesca
    Algarotti, Alessandra
    Mico, Caterina
    Grassi, Anna
    Deola, Sara
    Cavattoni, Irene
    Gaipa, Giuseppe
    Belotti, Daniela
    Perseghin, Paolo
    Parma, Matteo
    Pogliani, Enrico
    Golay, Josee
    Pedrini, Olga
    Capelli, Chiara
    Cortelazzo, Sergio
    D'Amico, Giovanna
    Biondi, Andrea
    Rambaldi, Alessandro
    Biagi, Ettore
    [J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2014, 20 (03) : 375 - 381
  • [62] Stem cell conditioned medium improves acute lung injury in mice: in vivo evidence for stem cell paracrine action
    Ionescu, Lavinia
    Byrne, Roisin N.
    van Haaften, Tim
    Vadivel, Arul
    Alphonse, Rajesh S.
    Rey-Parra, Gloria J.
    Weissmann, Gaia
    Hall, Adam
    Eaton, Farah
    Thebaud, Bernard
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2012, 303 (11) : L967 - L977
  • [63] Placenta-Derived Mesenchymal Stem Cells Have an Immunomodulatory Effect That Can Control Acute Graft-Versus-Host Disease in Mice
    Jang, Moon Ju
    Kim, Hye-Sun
    Lee, Hye-Gyn
    Kim, Gi Jin
    Jeon, Hwang Gyun
    Shin, Hyun-Soo
    Chang, Sei-Kyung
    Hur, Gin-Hyung
    Chong, So Young
    Oh, Doyeun
    Chung, Hyung-Min
    [J]. ACTA HAEMATOLOGICA, 2013, 129 (04) : 197 - 206
  • [64] Optimization of the therapeutic efficacy of human umbilical cord blood-mesenchymal stromal cells in an NSG mouse xenograft model of graft-versus-host disease
    Jang, Yun Kyung
    Kim, Miyeon
    Lee, Young-Ho
    Oh, Wonil
    Yang, Yoon Sun
    Choi, Soo Jin
    [J]. CYTOTHERAPY, 2014, 16 (03) : 298 - 308
  • [65] Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells
    Jiang, XX
    Zhang, Y
    Liu, B
    Zhang, SX
    Wu, Y
    Yu, XD
    Mao, N
    [J]. BLOOD, 2005, 105 (10) : 4120 - 4126
  • [66] Intra-Articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritis of the Knee: A Proof-of-Concept Clinical Trial
    Jo, Chris Hyunchul
    Lee, Young Gil
    Shin, Won Hyoung
    Kim, Hyang
    Chai, Jee Won
    Jeong, Eui Cheol
    Kim, Ji Eun
    Shim, Hackjoon
    Shin, Ji Sun
    Shin, Il Seob
    Ra, Jeong Chan
    Oh, Sohee
    Yoon, Kang Sup
    [J]. STEM CELLS, 2014, 32 (05) : 1254 - 1266
  • [67] Paracrine Factors of Multipotent Stromal Cells Ameliorate Lung Injury in an Elastase-induced Emphysema Model
    Katsha, Ahmed M.
    Ohkouchi, Shinya
    Xin, Hong
    Kanehira, Masahiko
    Sun, Ruowen
    Nukiwa, Toshihiro
    Saijo, Yasuo
    [J]. MOLECULAR THERAPY, 2011, 19 (01) : 196 - 203
  • [68] Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation
    Kebir, Hania
    Kreymborg, Katharina
    Ifergan, Igal
    Dodelet-Devillers, Aurore
    Cayrol, Romain
    Bernard, Monique
    Giuliani, Fabrizio
    Arbour, Nathalie
    Becher, Burkhard
    Prat, Alexandre
    [J]. NATURE MEDICINE, 2007, 13 (10) : 1173 - 1175
  • [69] Delivery of IL-12p40 ameliorates DSS-induced colitis by suppressing IL-17A expression and inflammation in the intestinal mucosa
    Kim, Doo-Jin
    Kim, Kwang-Soon
    Song, Mi-Young
    Seo, Sang-Hwan
    Kim, Su-Jin
    Yang, Bo-Gie
    Jang, Myoung-Ho
    Sung, Young-Chul
    [J]. CLINICAL IMMUNOLOGY, 2012, 144 (03) : 190 - 199
  • [70] The Therapeutic Effects of Optimal Dose of Mesenchymal Stem Cells in a Murine Model of an Elastase Induced-Emphysema
    Kim, You-Sun
    Kim, Ji-Young
    Huh, Jin Won
    Lee, Sei Won
    Choi, Soo Jin
    Oh, Yeon-Mok
    [J]. TUBERCULOSIS AND RESPIRATORY DISEASES, 2015, 78 (03) : 239 - 245
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