KF/Al2O3/PEG-400: An Efficient Catalytic System for the Fiesselmann-Type Synthesis of Thiophene Derivatives

被引：14

作者：

Bezboruah, Pranjal ^{[1
]}

Gogoi, Pranjal ^{[1
]}

Gogoi, Junali ^{[1
]}

Boruah, Romesh C. ^{[1
]}

机构：

[1] CSIR North East Inst Sci & Technol, Div Med Chem, Jorhat 785006, Assam, India

来源：

SYNTHESIS-STUTTGART | 2013年 / 45卷 / 10期

关键词：

Fiesselmann synthesis; KF/Al2O3/PEG-400; thiophene; unsaturated aldehyde; unsaturated nitrile; BIOLOGICAL EVALUATION; FLUORIDE; AGENT;

D O I：

10.1055/s-0033-1338299

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and mild protocol has been developed for the synthesis of novel steroidal and nonsteroidal thiophene derivatives from beta-halo-alpha,beta-unsaturated aldehydes using KF/Al2O3/PEG-400 as an efficient catalytic system. The beta-halo-alpha,beta-unsaturated aldehydes are synthesized from the corresponding ketones using Vilsmeier formylation reaction and converted into beta-halo-alpha, beta-unsaturated nitriles. The synthetic protocol is subsequently applied to the synthesis of 3-aminothiophene derivatives using beta-halo-alpha, beta-unsaturated nitriles.

引用

页码：1341 / 1348

页数：8

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