How does Lin28 let-7 control development and disease?

被引：328
作者：
Thornton, James E. [1 ,3 ]
Gregory, Richard I. [1 ,2 ,3 ]
机构：
[1] Childrens Hosp, Stem Cell Program, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA
[3] Harvard Stem Cell Inst, Boston, MA 02115 USA
来源：
TRENDS IN CELL BIOLOGY | 2012年 / 22卷 / 09期
基金：
美国国家科学基金会;
关键词：
Lin28; let-7; microRNA; TUTase; stem cells; development; cancer; GENOME-WIDE ASSOCIATION; BINDING PROTEIN LIN28; POSTTRANSCRIPTIONAL REGULATION; MICRORNA BIOGENESIS; PROMOTES TRANSFORMATION; C-ELEGANS; RNA; LIN-28; EXPRESSION; MYC;
D O I：
10.1016/j.tcb.2012.06.001
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
One of the most ancient and highly conserved microRNAs (miRNAs), the let-7 family, has gained notoriety owing to its regulation of stem cell differentiation and essential role in normal development, as well as its tumor suppressor function. Mechanisms controlling let-7 expression have recently been uncovered, specifically the role of the RNA-binding protein Lin28 - a key developmental regulator in blocking let-7 biogenesis. This review focuses on our current understanding of the Lin28-mediated control of let-7 maturation and highlights the central role of Lin28 in stem cell biology, development, control of glucose metabolism, and dysregulation in human disease. Manipulating the Lin28 pathway for the precise control of let-7 expression may provide novel therapeutic opportunities for cancer and other diseases.
引用
收藏
页码：474 / 482
页数：9
相关论文
共 79 条
[1]   HETEROCHRONIC MUTANTS OF THE NEMATODE CAENORHABDITIS-ELEGANS [J].
AMBROS, V ;
HORVITZ, HR .
SCIENCE, 1984, 226 (4673) :409-416
[2]   LIN28 alters cell fate succession and acts independently of the let-7 microRNA during neurogliogenesis in vitro [J].
Balzer, Erica ;
Heine, Christian ;
Jiang, Qiang ;
Lee, Vivian M. ;
Moss, Eric G. .
DEVELOPMENT, 2010, 137 (06) :891-900
[3]   Stem cell-like micro-RNA signature driven by Myc in aggressive liver cancer [J].
Cairo, Stefano ;
Wang, Yipeng ;
de Reynies, Aurelien ;
Duroure, Karine ;
Dahan, Jennifer ;
Redon, Marie-Jose ;
Fabre, Monique ;
McClelland, Michael ;
Wang, Xin W. ;
Croce, Carlo M. ;
Buendia, Marie-Annick .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (47) :20471-20476
[4]   RNA-binding protein LIN28 is a marker for testicular germ cell tumors [J].
Cao, Dengfeng ;
Allan, Robert W. ;
Cheng, Liang ;
Peng, Yan ;
Guo, Charies C. ;
Dahiya, Neha ;
Akhi, Shirin ;
Li, Jianping .
HUMAN PATHOLOGY, 2011, 42 (05) :710-718
[5]   RNA-binding protein LIN28 is a marker for primary extragonadal germ cell tumors: an immunohistochemical study of 131 cases [J].
Cao, Dengfeng ;
Liu, Aijun ;
Wang, Fenghua ;
Allan, Robert W. ;
Mei, Kaiyong ;
Peng, Yan ;
Du, Jun ;
Guo, Shuangping ;
Abel, Ty W. ;
Lane, Zhaoli ;
Ma, Joe ;
Rodriguez, Maria ;
Akhi, Shirin ;
Dehiya, Neha ;
Li, Jianping .
MODERN PATHOLOGY, 2011, 24 (02) :288-296
[6]   Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation [J].
Chang, Tsung-Cheng ;
Zeiteis, Lauren R. ;
Hwang, Hun-Way ;
Chivukula, Raghu R. ;
Wentzel, Erik A. ;
Dews, Michael ;
Jung, Jason ;
Gao, Ping ;
Dang, Chi V. ;
Beer, Michael A. ;
Thomas-Tikhonenko, Andrei ;
Mendell, Joshua T. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (09) :3384-3389
[7]   Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells [J].
Chekulaeva, Marina ;
Filipowicz, Witold .
CURRENT OPINION IN CELL BIOLOGY, 2009, 21 (03) :452-460
[8]   Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs [J].
Frost, Robert J. A. ;
Olson, Eric N. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (52) :21075-21080
[9]   Identification and characterization of lin-28 homolog B (LIN28B) in human hepatocellular carcinoma [J].
Guo, Yingqiu ;
Chen, Yongxin ;
Ito, Hirotaka ;
Watanabe, Akira ;
Ge, Xijin ;
Kodama, Tatsuhiko ;
Aburatani, Hiroyuki .
GENE, 2006, 384 :51-61
[10]   Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells [J].
Hagan, John P. ;
Piskounova, Elena ;
Gregory, Richard I. .
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2009, 16 (10) :1021-U33
12345678