Peptidome profiles and bioactivity elucidation of buffalo-milk dairy products after gastrointestinal digestion

被引：47

作者：

Basilicata, Manuela Giovanna ^{[1
,2
]}

Pepe, Giacomo ^{[1
,3
]}

Sommella, Eduardo ^{[1
]}

Ostacolo, Carmine ^{[4
]}

Manfra, Michele ^{[5
]}

Sosto, Gennaro ^{[6
]}

Pagano, Giuseppe ^{[7
]}

Novellino, Ettore ^{[4
]}

Campiglia, Pietro ^{[1
,8
]}

机构：

[1] Univ Salerno, Sch Pharm, Dept Pharm, Via Giovanni Paolo II 132, I-84084 Fisciano, SA, Italy

[2] Univ Salerno, PhD Program Drug Discovery & Dev, Via Giovanni Paolo II 132, I-84084 Fisciano, SA, Italy

[3] Pineta Grande Hosp, Via Domitiana, I-81130 Castelvolturno, CE, Italy

[4] Univ Naples Federico II, Dept Pharm, Via D Montesano 49, I-80131 Naples, Italy

[5] Univ Basilicata, Dept Sci, Viale Ateneo Lucano 10, I-85100 Potenza, Italy

[6] Azienda Sanit Reg Molise, Via Ugo Petrella 1, I-86100 Campobasso, Italy

[7] San Salvatore Dairy Factory, Via Dioniso, I-84050 Giungano, SA, Italy

[8] European Biomed Res Inst Salerno, Via Renzi 50, I-84125 Salerno, Italy

来源：

FOOD RESEARCH INTERNATIONAL | 2018年 / 105卷

关键词：

Buffalo-milk dairy product; In vitro gastrointestinal digestion; Bioactive peptides; High-resolution mass spectrometry; Bioaccessibility; RESOLUTION MASS-SPECTROMETRY; ENZYME-INHIBITORY PROPERTIES; VITRO INTESTINAL PROTECTION; BOVINE BETA-CASEIN; ANTIOXIDANT PEPTIDES; WHEY PROTEINS; LIQUID-CHROMATOGRAPHY; ACTIVE PEPTIDES; KAPPA-CASEIN; SKIM MILK;

D O I：

10.1016/j.foodres.2017.12.038

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Buffalo milk is highly appreciated for its nutritive properties and highly employed in dairy products, despite this the release of bioactive peptides has not been investigated thoroughly. The aim of this work was to characterize in detail the bioaccesible peptides from buffalo-milk dairy products. Six products were subjected to in vitro simulated gastrointestinal digestion and then analyzed by LC-HAMS. The identified peptides were 165 in Yoghurt, 152 in Scamorza, 146 in Mozzarella, 136 in Grana and Ricotta, 120 in Ice Cream samples, belonging to both buffalo caseins alpha(s1)-, beta-, k-CN) and whey proteins (alpha-LA, beta-LG). The identified peptide sequences were subjected to a database driven bioactivity search. Results highlighted a wide range of potential bioactive peptides, including antihypertensive, immunomodulatory, antimicrobial, antidiabetic, anticancer and antioxidant activity. These data evidence the content of healthy peptides released from buffalo-milk dairy products and suggest that the specific technological process influence their bioaccessibility.

引用

页码：1003 / 1010

页数：8

共 24 条

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