Attention-Deficit Hyperactivity Disorder and PharmacotherapyPast, Present, and Future: A Review of the Changing Landscape of Drug Therapy

被引：28

作者：

Connolly, J. J. ^{[1
]}

Glessner, J. T. ^{[2
,3
]}

Kao, C. ^{[1
]}

Elia, J. ^{[4
,5
,6
,7
]}

Hakonarson, H. ^{[8
]}

机构：

[1] Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 USA

[2] Massachusetts Gen Hosp, Ctr Human Genet Res, Mol Neurogenet Unit, Boston, MA 02114 USA

[3] Massachusetts Gen Hosp, Ctr Human Genet Res, Psychiat & Neurodev Genet Unit, Boston, MA 02114 USA

[4] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA

[5] Thomas Jefferson Univ, Dept Psychiat, Sidney Kimmel Med Coll, Philadelphia, PA 19107 USA

[6] Thomas Jefferson Univ, Dept Pediat, Sidney Kimmel Med Coll, Philadelphia, PA 19107 USA

[7] Univ Penn, Al Dupont Hosp Children, Philadelphia, PA 19104 USA

[8] Univ Penn, Sch Med, Dept Pediat, Philadelphia, PA 19104 USA

来源：

THERAPEUTIC INNOVATION & REGULATORY SCIENCE | 2015年 / 49卷 / 05期

关键词：

ADHD; pharmacotherapy; pharmacology; drug; medication; adverse events; COGNITION ENHANCER NS-105; METABOTROPIC GLUTAMATE RECEPTORS; ADENYLATE-CYCLASE ACTIVITY; DEFICIT/HYPERACTIVITY DISORDER; DOPAMINE TRANSPORTER; STIMULANT MEDICATION; PREFRONTAL CORTEX; METHYLPHENIDATE; ADHD; CHILDREN;

D O I：

10.1177/2168479015599811

中图分类号：

R-058 [];

学科分类号：

摘要：

Attention-deficit hyperactivity disorder (ADHD) is the most common neurobiological disorder in children. Efficacy of pharmacotherapy in treating ADHD symptoms has generally been considerable with at least three-fourths of individuals benefiting from pharmacotherapy, typically in the form of stimulants. In this review, we begin by briefly reviewing the history of pharmacotherapy in relation to ADHD, before focusing (primarily) on the state of the field on themes such as biophysiology, pharmacokinetics, and pharmacogenomics. We conclude with a summary of emerging clinical and research studies, particularly the potential role for precision therapy in matching ADHD patients and drug types.

引用

页码：632 / 642

页数：11

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