Mammalian Rho GTPases:: new insights into their functions from in vivo studies

被引：1446

作者：

Heasman, Sarah J. ^{[1
]}

Ridley, Anne J. ^{[1
]}

机构：

[1] Kings Coll London, Randall Div Cell & Mol Biophys, London SE1 IUL, England

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2008年 / 9卷 / 09期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/nrm2476

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Rho GTPases are key regulators of cytoskeletal dynamics and affect many cellular processes, including cell polarity, migration, vesicle trafficking and cytokinesis. These proteins are conserved from plants and yeast to mammals, and function by interacting with and stimulating various downstream targets, including actin nucleators, protein kinases and phospholipases. The roles of Rho GTPases have been extensively studied in different mammalian cell types using mainly dominant negative and constitutively active mutants. The recent availability of knockout mice for several members of the Rho family reveals new information about their roles in signalling to the cytoskeleton and in development.

引用

页码：690 / 701

页数：12

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