Excessive Supraventricular Ectopic Activity and Adverse Cardiovascular Outcomes: a Systematic Review and Meta-analysis

被引：19

作者：

Meng, Lei ^{[1
]}

Tsiaousis, Georgios ^{[2
]}

He, Jinli ^{[1
]}

Tse, Gary ^{[1
]}

Antoniadis, Antonios P. ^{[2
]}

Korantzopoulos, Panagiotis ^{[3
]}

Letsas, Konstantinos P. ^{[4
]}

Baranchuk, Adrian ^{[5
]}

Qi, Wenwei ^{[1
]}

Zhang, Zhiwei ^{[1
]}

Liu, Enzhao ^{[1
]}

Xu, Gang ^{[1
]}

Xia, Yunlong ^{[6
]}

Li, Guangping ^{[1
]}

Roever, Leonardo ^{[7
]}

Lip, Gregory Y. H. ^{[8
,9
,10
]}

Fragakis, Nikolaos ^{[2
]}

Liu, Tong ^{[1
]}

机构：

[1] Tianjin Med Univ, Hosp 2, Tianjin Inst Cardiol, Dept Cardiol,Tianjin Key Lab Lon Mol Funct Cardio, Tianjin 300211, Peoples R China

[2] Aristotle Univ Thessaloniki, Hippokrate Hosp, Cardiol Dept 3, Med Sch, Thessaloniki, Greece

[3] Univ Hosp Ioannina, Dept Cardiol 1, Ioannina, Greece

[4] Evangelismos Gen Hosp Athens, Dept Cardiol 2, Lab Cardiac Electrophysiol, Athens, Greece

[5] Queens Univ, Kingston Gen Hosp, Div Cardiol, Kingston, ON, Canada

[6] Dalian Med Univ, Dept Cardiovasc Med, Affiliated Hosp 1, Dalian, Peoples R China

[7] Univ Fed Uberlandia, Dept Clin Res, Uberlandia, MG, Brazil

[8] Univ Liverpool, Liverpool Ctr Cardiovasc Sci, Liverpool, Merseyside, England

[9] Liverpool Heart & Chest Hosp, Liverpool, Merseyside, England

[10] Aalborg Univ, Dept Clin Med, Aalborg Thrombosis Res Unit, Aalborg, Denmark

来源：

CURRENT ATHEROSCLEROSIS REPORTS | 2020年 / 22卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Excessive supraventricular ectopy; Atrial fibrillation; Stroke; Mortality; PAROXYSMAL ATRIAL-FIBRILLATION; VENTRICULAR PREMATURE COMPLEXES; CARDIAC-ARRHYTHMIAS; ISCHEMIC-STROKE; ELECTROCARDIOGRAPHIC PREDICTORS; PROGNOSTIC-SIGNIFICANCE; RISK-FACTOR; BEATS; INITIATION; HEART;

D O I：

10.1007/s11883-020-0832-4

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Purpose of ReviewExcessive supraventricular ectopic activity (ESVEA), in the form of frequent premature atrial contractions (PACs) and runs of PACs, is commonly observed in clinical practice and is frequently considered to be benign. Yet, recent studies have demonstrated a link between ESVEA and adverse cardiovascular outcomes. The aim of this meta-analysis was to examine the association between ESVEA and the risk of atrial fibrillation (AF), stroke, and mortality.Recent FindingsA systematic search was performed in PubMed, EMBASE, and the Cochrane Library up to December 2017 to identify studies assessing adverse cardiovascular outcomes in patients with ESVEA, recorded on ambulatory electrocardiography. ESVEA was defined as a burden of PACs >30 PACs/h or any runs of >= 20 PACs. The risk estimates for EVSEA and each clinical endpoint were pooled and analyzed separately.ResultsFive studies comprising 7545 participants were included in this meta-analysis. The pooled analysis showed that ESVEA doubled the risk of AF (HR 2.19, 95% CI 1.70-2.82). ESVEA was also associated with a higher incidence of stroke (HR 2.23, 95% CI 1.24-4.02). Finally, ESVEA was associated with higher all-cause mortality (HR 1.61, 95% CI 1.25-2.07).SummaryOur meta-analysis found that ESVEA is closely associated with AF, stroke, and all-cause mortality. Further studies are required to examine the implication of therapeutic strategies in patients with ESVEA, in order to prevent potential subsequent adverse cardiovascular outcomes.

引用

页数：9

共 58 条

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