CD44 and Hematologic Malignancies

被引：0
作者：
Liu, Jianing [1 ]
Jiang, Guosheng [1 ]
机构：
[1] Shandong Acad Med Sci, Inst Basic Med, Dept Hematol Oncol, Jinan 250062, Shandong, Peoples R China
来源：
CELLULAR & MOLECULAR IMMUNOLOGY | 2006年 / 3卷 / 05期
关键词：
CD44; hematological malignancy; prognosis; therapy;
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The expression of CD44 was upregulated in some hematological malignancies and is associated with metastasis and prognosis. The ligation of CD44 with specific monoclonal antibodies can trigger terminal differentiation of leukemic blasts in some subtypes, so it is probable to develop an anti-CD44 based differentiation therapy in leukemia. The effects of CD44 and its monoclonal antibodies are discussed in this review.
引用
收藏
页码：359 / 365
页数：7
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