Synthesis of Novel 5,6-Dihydropyrrolo[2,1-a]isoquinolines via Grob Reaction between (E)-1,1,1-Trifluoro-3-nitro-2-butene and 3,4-Dihydroisoquinolines

被引：10
|
作者：
Korotaev, Vladislav Y. [1 ]
Sosnovskikh, Vyacheslav Y. [1 ]
Barkov, Alexey Y. [1 ]
Slepukhin, Pavel A. [2 ]
Shklyaev, Yurii V. [3 ]
机构：
[1] Ural State Univ, Dept Chem, Ekaterinburg 620083, Russia
[2] Russian Acad Sci, Ural Branch, Inst Organ Synth, Ekaterinburg 620041, Russia
[3] Russian Acad Sci, Ural Branch, Inst Tech Chem, Perm 614600, Russia
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2012年 / 49卷 / 04期
关键词：
ENANTIOSELECTIVE SYNTHESIS; MICHAEL ADDITION; 3-STEP SYNTHESIS; NITRO-OLEFINS; DERIVATIVES; (+/-)-CRISPINE-A; NITROALKENES; 1,3,3-TRIMETHYL-3,4-DIHYDROISOQUINOLINE; ALKALOIDS; PYRROLES;
D O I：
10.1002/jhet.881
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Uncatalyzed cycloaddition of 3,4-dihydroisoquinolines to (E)-1,1,1-trifluoro-3-nitro-2-butene via Grob reaction provide a simple one-step route to the 5,6-dihydropyrrolo[2,1-a]isoquinolines, which represent the basic structural framework of the antitumor active alkaloid crispine.
引用
收藏
页码：856 / 860
页数：5
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