Thymic enlargement in a patient with juvenile idiopathic arthritis during etanercept therapy

被引：5

作者：

Sari, Ismail ^{[1
]}

Binicier, Omer ^{[1
]}

Birlik, Merih ^{[1
]}

Akar, Servet ^{[1
]}

Yilmaz, Erkan ^{[2
]}

Kargi, Aydanur ^{[3
]}

Onen, Fatos ^{[1
]}

Akkoc, Nurullah ^{[1
,4
]}

机构：

[1] Dokuz Eylul Univ, Dept Internal Med, Sch Med, Div Rheumatol, TR-35340 Izmir, Turkey

[2] Dokuz Eylul Univ, Sch Med, Dept Radiol, TR-35340 Izmir, Turkey

[3] Dokuz Eylul Univ, Dept Pathol, Sch Med, TR-35340 Izmir, Turkey

[4] Dokuz Eylul Univ, Tip Fak Ic Hastaliklari, ABD Immunol Romatol, TR-35340 Izmir, Turkey

来源：

RHEUMATOLOGY INTERNATIONAL | 2009年 / 29卷 / 05期

关键词：

Tumor necrosis factor alpha inhibitors; Adverse effects; LYMPHOID-TISSUE;

D O I：

10.1007/s00296-008-0726-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Tumor necrosis factor (TNF) alpha inhibitors are effective in the treatment of inflammatory rheumatic diseases. Despite their effectiveness, anti-TNF drugs have some drawbacks such as severe adverse effects including infections and possibly lymphoproliferative disorders. In this report we described a case of juvenile idiopathic arthritis patient who developed thymic enlargement (true thymic hyperplasia), mediastinal lymphadenopathy and pleurisy associated with systemic symptoms under Etanercept treatment. The clinical presentation was highly suggestive of malignancy and the patient underwent diagnostic mediastinoscopy with biopsy.

引用

页码：591 / 593

页数：3

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