Multiscale meshfree analysis of the effects of thermal treatments on deformability of red blood cell membrane

被引：6
作者：
Ademiloye, A. S. [1 ]
Liew, K. M. [1 ]
Zhang, L. W. [2 ]
机构：
[1] City Univ Hong Kong, Dept Architecture & Civil Engn, Kowloon, Hong Kong, Peoples R China
[2] Shanghai Ocean Univ, Coll Informat Technol, Shanghai 201306, Peoples R China
来源：
2016 IEEE 16TH INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOENGINEERING (BIBE) | 2016年
基金：
中国国家自然科学基金;
关键词：
Red blood cell; membrane deformability; temperature effects; optical tweezers; meshfree meshless methods; multiscale simulation; MODEL;
D O I：
10.1109/BIBE.2016.43
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
From the temperature condition in blood storage units before transfusion to those observed in patients with severe thermal burns, it is obvious that the human blood cells are subjected to various temperature ranges and changes throughout their lifespan. It is also known that temperature affects the ability of blood cell to transverse thin microcapillaries though the extent remains unknown. In this paper, we investigate the effects of freezing and heating temperatures on the deformability of the human red blood cell (RBC) membrane using a three-dimensional (3D) nonlinear multiscale meshfree approach. The optical tweezers experiment was numerically simulated in order to quantify the deformability of red blood cells as a function of the relationship between its deformed axial and transverse diameter. The results obtained showed that the deformability of red blood cell membrane decreases as the temperature rises. This observation confirms that increase in temperature results to increase in membrane rigidity and decrease in overall membrane deformability, which is mainly due to membrane protein denaturation.
引用
收藏
页码：186 / 191
页数：6
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