The short and the long: non-coding RNAs and growth factors in cancer progression

被引：20

作者：

Sas-Chen, Aldema ^{[1
]}

Srivastava, Swati ^{[1
]}

Yarden, Yosef ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Regulat Biol, Rehovot, Israel

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2017年 / 45卷

基金：

欧洲研究理事会;

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; NEGATIVE BREAST-CANCER; INVASION-METASTASIS CASCADE; CELL-PROLIFERATION; MEDIATED TRANSFER; REGULATES GROWTH; CARCINOMA-CELLS; GENE-EXPRESSION; POOR-PROGNOSIS; OVARIAN-CANCER;

D O I：

10.1042/BST20160131

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A relatively well-understood multistep process enables mutation-bearing cells to form primary tumours, which later use the circulation system to colonize new locations and form metastases. However, in which way the emerging abundance of different non-coding RNAs supports tumour progression is poorly understood. Here, we review new lines of evidence linking long and short types of non-coding RNAs to signalling pathways activated in the course of cancer progression by growth factors and by the tumour micro-environment. Resolving the new dimension of non-coding RNAs in oncogenesis will probably translate to earlier detection of cancer and improved therapeutic strategies.

引用

页码：51 / 64

页数：14

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