Toll-like receptors and cancer

被引：727
作者：
Rakoff-Nahoum, Seth [1 ,2 ]
Medzhitov, Ruslan [1 ,2 ]
机构：
[1] Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06510 USA
[2] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06510 USA
来源：
NATURE REVIEWS CANCER | 2009年 / 9卷 / 01期
关键词：
NF-KAPPA-B; NONPARENCHYMAL LIVER-CELLS; BACILLUS-CALMETTE-GUERIN; INDUCED TUMOR-GROWTH; DENDRITIC CELLS; SEQUENCE VARIANTS; CUTTING EDGE; INTESTINAL TUMORIGENESIS; STREPTOCOCCAL PREPARATION; MYD88-DEFICIENT MICE;
D O I：
10.1038/nrc2541
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Toll-like receptors (TLRs) are a family of pattern recognition receptors that are best-known for their role in host defence from infection. Emerging evidence also suggests that TLRs have an important role in maintaining tissue homeostasis by regulating the inflammatory and tissue repair responses to injury. The development of cancer has been associated with microbial infection, injury, inflammation and tissue repair. Here we discuss how the function of TLRs may relate to these processes in the context of carcinogenesis.
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收藏
页码：57 / 63
页数：7
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