Synthesis and Antimicrobial Evaluation of a New Series of N-1,3-Benzothiazol-2-ylbenzamides

被引：7

作者：

Armenise, Domenico ^{[1
]}

Carocci, Alessia ^{[1
]}

Catalano, Alessia ^{[1
]}

Muraglia, Marilena ^{[1
]}

Defrenza, Ivana ^{[1
]}

De Laurentis, Nicolino ^{[1
]}

Rosato, Antonio ^{[1
]}

Corbo, Filomena ^{[1
]}

Franchini, Carlo ^{[1
]}

机构：

[1] Univ Bari Aldo Moro, Dipartimento Farm Sci Farmaco, I-70125 Bari, Italy

来源：

JOURNAL OF CHEMISTRY | 2013年 / 2013卷

关键词：

IN-VITRO; BENZOTHIAZOLE DERIVATIVES; COMBINATORIAL SYNTHESIS; BIOLOGICAL EVALUATION; RESISTANCE; BLOCKERS; ANALOGS; DESIGN;

D O I：

10.1155/2013/181758

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Enterococcus faecalis is a Gram-positive commensal inhabitant of the intestinal tract of humans, animals, and insects. However, it is also an opportunistic pathogen and has emerged as a leading cause of hospital-acquired extraintestinal infections. Fluoroquinolones have been frequently used to treat E. faecalis infections, and the emergence of fluoroquinolone-resistant E. faecalis strains has recently been reported in several countries. Thus, the identifications of new antibiotics specifically directed to E. faecalis may be envisaged. In this paper, a new series of N-1,3-benzothiazol-2-ylbenzamides have been designed, synthesized, and evaluated for their in vitro antimicrobial activities. Among the tested compounds, 3i was active against E. faecalis.

引用

页数：7

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