Bayesian adaptive group lasso with semiparametric hidden Markov models

被引:10
|
作者
Kang, Kai [1 ]
Song, Xinyuan [1 ,2 ]
Hu, X. Joan [3 ]
Zhu, Hongtu [4 ,5 ]
机构
[1] Chinese Univ Hong Kong, Dept Stat, Shatin, Hong Kong, Peoples R China
[2] Chinese Univ Hong Kong, Shenzhen Res Inst, Shatin, Hong Kong, Peoples R China
[3] Simon Fraser Univ, Dept Stat & Actuarial Sci, Burnaby, BC, Canada
[4] Univ N Carolina, Dept Biostat, Chapel Hill, NC 27515 USA
[5] Univ N Carolina, Biomed Res Imaging Ctr, Chapel Hill, NC 27515 USA
基金
中国国家自然科学基金; 加拿大自然科学与工程研究理事会; 加拿大健康研究院;
关键词
linear basis expansion; Markov chain Monte Carlo; simultaneous model selection and estimation; LATENT VARIABLE MODELS; ALZHEIMERS-DISEASE; REGRESSION; SELECTION; HIPPOCAMPAL; COEFFICIENT; SHRINKAGE; EDUCATION; DECLINE; TIME;
D O I
10.1002/sim.8051
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
This paper presents a Bayesian adaptive group least absolute shrinkage and selection operator method to conduct simultaneous model selection and estimation under semiparametric hidden Markov models. We specify the conditional regression model and the transition probability model in the hidden Markov model into additive nonparametric functions of covariates. A basis expansion is adopted to approximate the nonparametric functions. We introduce multivariate conditional Laplace priors to impose adaptive penalties on regression coefficients and different groups of basis expansions under the Bayesian framework. An efficient Markov chain Monte Carlo algorithm is then proposed to identify the nonexistent, constant, linear, and nonlinear forms of covariate effects in both conditional and transition models. The empirical performance of the proposed methodology is evaluated via simulation studies. We apply the proposed model to analyze a real data set that was collected from the Alzheimer's Disease Neuroimaging Initiative study. The analysis identifies important risk factors on cognitive decline and the transition from cognitive normal to Alzheimer's disease.
引用
收藏
页码:1634 / 1650
页数:17
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