Polymorphism of the apolipoprotein E gene and risk of multiple sclerosis in ethnic Russians

被引：0
|
作者：
Mustafina, O. E. [1 ]
Mikhailova, A. M. [1 ]
Bakhtiyarova, K. Z. [2 ]
Nasibulin, T. R. [1 ]
Tuktarova, I. A. [1 ]
Makarycheva, O. Yu. [3 ]
Sudomoina, M. A. [3 ]
Boiko, A. N. [3 ]
Voronchikhina, S. A. [4 ]
Volkova, L. I. [4 ]
Magzhanov, R. V. [2 ]
Favorova, O. O. [3 ]
机构：
[1] Russian Acad Sci, Ufa Sci Ctr, Inst Biochem & Genet, Ufa 450054, Russia
[2] Bashkir State Med Univ, Ufa 450000, Russia
[3] Russian State Med Univ, Moscow 117997, Russia
[4] Reg Clin Hosp 1, Ekaterinburg 620102, Russia
来源：
MOLECULAR BIOLOGY | 2008年 / 42卷 / 06期
关键词：
human genomics; apolipoprotein E; APOE gene; allele; polymorphism; multiple sclerosis; Russian ethnic group;
D O I：
10.1134/S0026893308060046
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Multiple sclerosis (MS) is a multifactorial disease of the central nervous system with pronounced hereditary predisposition. The purpose of the study was to test the assumption on the involvement of the apolipoprotein E gene (APOE) polymorphism in exon 4 in the development of MS in ethnic Russians. Samples independently collected in Moscow (106 MS cases and 189 control healthy volunteers), Sverdlovsk oblast (54 and 109, respectively), and the Republic of Bashkortostan (119 and 285, respectively) were examined. Genotypes for 2059C/T and 2197C/T polymorphisms of the APOE gene, which determine the amino acid substitutions C112R and R158C in apolipoprotein E, were analyzed by polymerase chain reaction followed by restriction analysis of amplificates. No statistically significant differences in genotype or allele frequencies were found between the control group and the group of MS cases. The APOE*4 allele is not associated with the risk of MS in ethnic Russians.
引用
收藏
页码：852 / 858
页数：7
相关论文
共 50 条
  • [21] Apolipoprotein E Gene Polymorphism and Gender
    Kolovou, Genovefa
    Damaskos, Dimitris
    Anagnostopoulou, Katherine
    Cokkinos, Dennis V.
    ANNALS OF CLINICAL AND LABORATORY SCIENCE, 2009, 39 (02) : 120 - 133
  • [22] Association between apolipoprotein E gene polymorphism and depression
    Feng, Fang
    Lu, Shan-Shan
    Hu, Cai-Yun
    Gong, Feng-Feng
    Qian, Zhen-Zhong
    Yang, Hui-Yun
    Wu, Yi-Le
    Zhao, Yuan-Yuan
    Bi, Peng
    Sun, Ye-Huan
    JOURNAL OF CLINICAL NEUROSCIENCE, 2015, 22 (08) : 1232 - 1238
  • [23] GENE POLYMORPHISM OF APOLIPOPROTEIN E AND CORTICAL CEREBRAL INFARCTION
    张颖冬
    梁秀龄
    Chinese Medical Sciences Journal, 1998, (04) : 57 - 60
  • [24] Apolipoprotein E Gene Polymorphism and the Risk of Intracerebral Hemorrhage in the Chinese Population
    Zhang, Rongjun
    Wang, Xiaofeng
    Liu, Jianxin
    Yang, Shuzhen
    Tang, Zongchun
    Li, Shuande
    Peng, Yabin
    Zhang, Hongbin
    Yang, Xingkui
    Zhou, Yongchun
    Shao, Wei
    GENETIC TESTING AND MOLECULAR BIOMARKERS, 2012, 16 (01) : 63 - 66
  • [25] Polymorphisms of apolipoprotein E; outcome and susceptibility in multiple sclerosis
    Weatherby, SJM
    Mann, CLA
    Davies, MB
    Carthy, D
    Fryer, AA
    Boggild, MD
    Young, C
    Strange, RC
    Ollier, W
    Hawkins, CP
    MULTIPLE SCLEROSIS, 2000, 6 (01): : 32 - 36
  • [26] Apolipoprotein E and multiple sclerosis: A biochemical and genetic investigation
    Gaillard, O
    Gervais, A
    Meillet, D
    Plassart, E
    Fontaine, B
    Lyon-Caen, O
    Delattre, J
    Schuller, E
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 1998, 158 (02) : 180 - 186
  • [27] A rapid and cost-effective method for genotyping apolipoprotein E gene polymorphism
    Zhong, Li
    Xie, Yong-Zhuang
    Cao, Tian-Tian
    Wang, Zongqi
    Wang, Tingting
    Li, Xinxiu
    Shen, Rui-Chi
    Xu, Huaxi
    Bu, Guojun
    Chen, Xiao-Fen
    MOLECULAR NEURODEGENERATION, 2016, 11
  • [28] The impact of our genes: Consequences of the apolipoprotein E polymorphism in Alzheimer disease and multiple sclerosis
    Fazekas, Franz
    Enzinger, Christian
    Ropele, Stefan
    Schmidt, Helena
    Schmidt, Reinhold
    Strasser-Fuchs, Siegrid
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2006, 245 (1-2) : 35 - 39
  • [29] Apolipoprotein E polymorphism and the risk of aneurysmal subarachnoid hemorrhage in a South Indian population
    Suvatha, Arati
    Kandi, Sibin Madathan
    Bhat, Dhananjaya Ishwara
    Rao, Narasinga
    Vazhayil, Vikas
    Kasturirangan, Chetan Ghati
    CELLULAR & MOLECULAR BIOLOGY LETTERS, 2017, 22
  • [30] Apolipoprotein E gene polymorphism and allele frequencies in the lebanese population
    Mahfouz, Rami A. R.
    Sabbagh, Amira S.
    Zahed, Laila F.
    Mahfoud, Ziyad R.
    Kalmoni, Rana F.
    Otrock, Zaher K.
    Taher, Ali T.
    Zaatari, Ghazi S.
    MOLECULAR BIOLOGY REPORTS, 2006, 33 (02) : 145 - 149
12345