Solvent-free microwave synthesis of 4-hydroxy-3-phenylquinolin-2(1H)-ones and variants using activated arylmalonates

被引：33

作者：

Rivkin, A ^{[1
]}

Adams, B ^{[1
]}

机构：

[1] Merck Res Labs, Dept Chem, Boston, MA 02115 USA

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 14期

关键词：

4-Hydroxy-2(1H)-pyridones; 4-Hydroxyquinolin-2(1H)-ones; Di-(2,4,6-trichlorophenyl)-2-phenylmalonate; Microwave reaction; Pharmaceutical agents;

D O I：

10.1016/j.tetlet.2006.01.148

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The disclosure herein describes the rapid synthesis of 4-hydroxy-3-phenylquinolin-2(1H)-ones and variants via it solvent-free microwave cyclocondensation reaction using di-(2,4,6-trichlorophenyl)-2-phenylmalonate, which improves the general scope of this reaction. (c) 2006 Elsevier Ltd. All rights reserved.

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页码：2395 / 2398

页数：4

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