Endocan: A novel biomarker for risk stratification, prognosis and therapeutic monitoring in human cardiovascular and renal diseases

被引:35
作者
Bessa, Joao [1 ]
Albino-Teixeira, Antonio [1 ,2 ]
Reina-Couto, Marta [1 ,2 ,3 ]
Sousa, Teresa [1 ,2 ]
机构
[1] Fac Med Univ Porto FMUP, Unidade Farrnacol & Terapeut, Dept Biomed, Porto, Portugal
[2] Univ Porto, Ctr Invest Farrnacol & Inovacao Medicamentosa Med, Porto, Portugal
[3] Ctr Hosp Sao Joao CHSJ, Dept Med Intens, Porto, Portugal
关键词
Endocan; Inflammation; Endothelial dysfunction; Cardiovascular diseases; Biomarker; Risk stratification; CELL-SPECIFIC MOLECULE-1; CHRONIC KIDNEY-DISEASE; ENDOTHELIUM-DEPENDENT VASODILATION; ELEVATION MYOCARDIAL-INFARCTION; CORONARY-ARTERY-DISEASE; INTIMA-MEDIA THICKNESS; CHRONIC HEART-FAILURE; SERUM ENDOCAN; ADHESION MOLECULES; NITRIC-OXIDE;
D O I
10.1016/j.cca.2020.07.041
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
The vascular endothelium is localized at the interface between the blood and surrounding tissues, playing a pivotal role in the maintenance of tissue-fluid homeostasis and in the regulation of host defense, inflammation, vascular tone and remodeling, angiogenesis and haemostasis. The dysfunctional endothelium was shown to be implicated in the pathophysiology of several endothelial-dependent disorders, such as arterial hypertension, coronary artery disease, heart failure and chronic kidney disease, in which it is an early predictor of cardiovascular events. Endocan is a soluble dermatan sulphate proteoglycan mainly secreted by the activated endothelium. It is upregulated by several proinflammatory cytokines and proangiogenic factors and may itself contribute to the inflammatory status. In addition of being a surrogate marker of inflammation and endothelial dysfunction, it seems to be involved in the regulation of several proliferative and neovascularization processes. Therefore, its utility as a biomarker in a wide spectrum of diseases has been increasingly explored. Here, we review the current evidence concerning the role of endocan in several human cardiovascular and renal diseases, where it seems to be a promising biomarker for risk stratification, prognosis and therapeutic monitoring.
引用
收藏
页码:310 / 335
页数:26
相关论文
共 208 条
[1]   Endocan, a putative endothelial cell marker, is elevated in preeclampsia, decreased in acute pyelonephritis, and unchanged in other obstetrical syndromes [J].
Adekola, Henry ;
Romero, Roberto ;
Chaemsaithong, Piya ;
Korzeniewski, Steven J. ;
Dong, Zhong ;
Yeo, Lami ;
Hassan, Sonia S. ;
Chaiworapongsa, Tinnakorn .
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 2015, 28 (14) :1621-1632
[2]   Is endocan a biochemical marker for asymptomatic target organ damage in hypertensive patients? [J].
Agac, Mustafa Tarik ;
Kahyaoglu, Behlul ;
Aksoy, Muhammed Murat Necati ;
Cinemre, Fatma Behice ;
Vatan, Mehmet Bulent ;
Gunduz, Yasemin .
ANATOLIAN JOURNAL OF CARDIOLOGY, 2019, 21 (02) :76-82
[3]   The endothelium: physiological functions and role in microcirculatory failure during severe sepsis [J].
Ait-Oufella, H. ;
Maury, E. ;
Lehoux, S. ;
Guidet, B. ;
Offenstadt, G. .
INTENSIVE CARE MEDICINE, 2010, 36 (08) :1286-1298
[4]   Incremental Prognostic Significance of Peripheral Endothelial Dysfunction in Patients With Heart Failure With Normal Left Ventricular Ejection Fraction [J].
Akiyama, Eiichi ;
Sugiyama, Seigo ;
Matsuzawa, Yasushi ;
Konishi, Masaaki ;
Suzuki, Hiroyuki ;
Nozaki, Toshimitsu ;
Ohba, Keisuke ;
Matsubara, Junichi ;
Maeda, Hirofumi ;
Horibata, Yoko ;
Sakamoto, Kenji ;
Sugamura, Koichi ;
Yamamuro, Megumi ;
Sumida, Hitoshi ;
Kaikita, Koichi ;
Iwashita, Satomi ;
Matsui, Kunihiko ;
Kimura, Kazuo ;
Umemura, Satoshi ;
Ogawa, Hisao .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2012, 60 (18) :1778-1786
[5]   Endothelial Dysfunction in Chronic Heart Failure: Assessment, Findings, Significance, and Potential Therapeutic Targets [J].
Alem, Manal M. .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (13)
[6]  
Alexander Y., 2020, CARDIOVASC RES
[7]   Effect of CPAP on New Endothelial Dysfunction Marker, Endocan, in People With Obstructive Sleep Apnea [J].
Altintas, Nejat ;
Mutlu, Levent Cem ;
Akkoyun, Dursun Cayan ;
Aydin, Murat ;
Bilir, Bulent ;
Yilmaz, Ahsen ;
Malhotra, Atul .
ANGIOLOGY, 2016, 67 (04) :364-374
[8]  
Andrews TC, 1997, CIRCULATION, V95, P324
[9]   Ticagrelor Increases SIRT1 and HES1 mRNA Levels in Peripheral Blood Cells from Patients with Stable Coronary Artery Disease and Chronic Obstructive Pulmonary Disease [J].
Aquila, Giorgio ;
Dalla Sega, Francesco Vieceli ;
Marracino, Luisa ;
Pavasini, Rita ;
Cardelli, Laura Sofia ;
Piredda, Anna ;
Scoccia, Alessandra ;
Martino, Valeria ;
Fortini, Francesca ;
Bononi, Ilaria ;
Martini, Fernanda ;
Manfrini, Marco ;
Pannuti, Antonio ;
Ferrari, Roberto ;
Rizzo, Paola ;
Campo, Gianluca .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (05)
[10]   Effect of Glycemic Regulation on Endocan Levels in Patients With Diabetes: A Preliminary Study [J].
Arman, Yucel ;
Akpinar, Timur Selcuk ;
Kose, Murat ;
Emet, Samim ;
Yuruyen, Gulden ;
Akarsu, Murat ;
Ozcan, Mustafa ;
Yegit, Ozan ;
Cakmak, Ramazan ;
Altun, Ozgur ;
Aydin, Sengul ;
Alibeyoglu, Alpay ;
Ugurlu, Bilal ;
Akcan, Tugce ;
Tukek, Tufan .
ANGIOLOGY, 2016, 67 (03) :239-244