The association between polymorphisms of genes related to inflammation and recurrent pregnancy loss

被引：8
|
作者：
Gu, Yan [1 ]
Wang, Jian Mei [1 ]
Zhang, Zhao Feng [2 ]
Wang, Jian [2 ]
Cao, Yun Lei [2 ]
Pan, Cai Jun [1 ]
Yin, Li Rong [1 ]
Du, Jing [2 ]
机构：
[1] Tianjin Med Univ, Hosp 2, Tianjin, Peoples R China
[2] Fudan Univ, Key Lab Reprod Regulat NPFPC, SIPPR, IRD, Shanghai, Peoples R China
来源：
GYNECOLOGICAL ENDOCRINOLOGY | 2018年 / 34卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Reproductive immunology; genetics; recurrent pregnancy loss; DNA METHYLATION; CPG ISLANDS; UBIQUITINATION; DISEQUILIBRIUM; UBIQUITYLATION; TRANSCRIPTION; MISCARRIAGE; MECHANISMS; INFECTION; APOPTOSIS;
D O I：
10.1080/09513590.2017.1395837
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Aim: Recurrent pregnancy loss (RPL) occurs in 1-2% of pregnant women and about 50% of RPL cases are unexplained. Previous studies have shown that genetic variation in immune response genes can contribute to the risk in pregnancy maintenance during pregnancy. The aim of the present study was to evaluate the relationship between RPL and genes those have previously been associated with an inflammatory process on 107 RPL cases and 187 healthy controls.Methods: In this work, the single-nucleotide polymorphisms was examined by utilizing the direct sequencing and the Sequenom MassARRAY system.Results: The FAU rs769440G allele had higher frequencies in patients with RPL (p=.019). No association was observed between other polymorphisms and RPL.Conclusion: The results showed an association between FAU rs769440 polymorphism and RPL in Chinese Han population.
引用
收藏
页码：349 / 352
页数：4
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