2,3,7,8-Tetrachlorodibenzo-p-dioxin suppress AChE activity in NGF treated PC12 cells

被引：5
|
作者：
Xu, Li [1 ]
Chen, Yangsheng [1 ]
Xie, Heidi Q. H. [1 ]
Xu, Tuan [1 ]
Fu, Hualing [1 ]
Zhang, Songyan [1 ]
Tsim, Karl W. K. [2 ]
Bi, Cathy W. C. [2 ]
Zhao, Bin [1 ]
机构：
[1] Univ Chinese Acad Sci, Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China
[2] Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Hong Kong, Peoples R China
来源：
CHEMICO-BIOLOGICAL INTERACTIONS | 2016年 / 259卷
基金：
中国国家自然科学基金;
关键词：
AChE; Acetylcholinesterase; Dioxin; 2,3,7,8-TCDD; PC12; Neuronal differentiation; NGF; Nerve growth factor; DIOXIN-LIKE COMPOUNDS; RICH MEMBRANE ANCHOR; ACETYLCHOLINESTERASE ACTIVITY; NEURONAL DIFFERENTIATION; NEURITE OUTGROWTH; IN-VITRO; PATHWAY; OLIGOMERIZATION; QUANTIFICATION; EXPRESSION;
D O I：
10.1016/j.cbi.2016.08.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
PC12 is a well studied cell model for neuronal differentiation. AChE is also considered as a marker for neuronal differentiation. In this study, we detected the change of AChE activity during the NGF induced differentiation of PC 12 cells, and targeted on the ratio of the activity of AChE on the cell surface, and found that NGF mainly increased the intracellular AChE activity. Dioxin is a kind of persistent organic pollutants which have extreme impact on human health and widely distributed all over the world. Recently, AChE was reported as a target of the toxicity of dioxin. Here we investigated the effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on AChE activity in the PC12 cells, and found that at the later stage of differentiation, TCDD could decrease the AChE activity. This down regulation might not related to transcriptional regulation. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：282 / 285
页数：4
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