Effects of Epigallocatechin-3-gallate (EGCG) on A549 Lung Cancer Tumor Growth and Angiogenesis

被引：51

作者：

Sakamoto, Yuhi ^{[1
]}

Terashita, Nobuhiro ^{[1
]}

Muraguchi, Takashi ^{[1
]}

Fukusato, Toshio ^{[2
]}

Kubota, Shunichiro ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Arts & Sci, Dept Life Sci, Tokyo 1538902, Japan

[2] Teikyo Univ, Dept Pathol, Sch Med, Tokyo 1738605, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2013年 / 77卷 / 09期

关键词：

epigallocatechin 3-gallate (EGCG); endostatin; angiogenesis; vascular endothelial growth factor (VEGF); nude mouse; GREEN TEA; (-)-EPIGALLOCATECHIN GALLATE; SIGNALING PATHWAYS; VEGF INDUCTION; INHIBITION; CARCINOMA; APOPTOSIS; CATECHINS; CELLS; OVEREXPRESSION;

D O I：

10.1271/bbb.120882

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Epigallocatechin 3-gallate (EGCG) has cytotoxic effects in many cancer cells. It has been reported that A549 lung cancer cells are markedly resistant to cell death induced by EGCG. In the present study, the effects of EGCG on A549 lung cancer cell growth and angiogenesis were studied. We found that EGCG dose-dependently suppressed A549 cell growth, while A549 cells were markedly resistant to cell death in vitro. Next we found that EGCG increased endostatin expression and suppressed vascular endothelial growth factor (VEGF) expression. We further studied to determine whether EGCG would suppress A549 tumor growth in nude mouse and angiogenesis. EGCG in drinking water significantly suppressed A549 tumor growth in nude mice. Histological analysis revealed that the number of CD34 positive vessels had a tendency to decrease in the tumor. In sum, EGCG had anti-proliferative effects of A549 on tumor growth and showed a tendency to suppress angiogenesis.

引用

页码：1799 / 1803

页数：5

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