Gap Junction Remodeling in Skin Repair Following Wounding and Disease

被引：55
作者：
Churko, Jared M. [1 ]
Laird, Dale W. [1 ]
机构：
[1] Univ Western Ontario, Dept Anat & Cell Biol, London, ON, Canada
来源：
PHYSIOLOGY | 2013年 / 28卷 / 03期
关键词：
DOMINANT CONNEXIN DISORDERS; DENTO-DIGITAL DYSPLASIA; KERATINOCYTE DIFFERENTIATION; ERYTHROKERATODERMIA-VARIABILIS; HYPERPROLIFERATIVE EPIDERMIS; OCULODENTODIGITAL DYSPLASIA; INTERCELLULAR COMMUNICATION; PALMOPLANTAR KERATODERMA; MUTANT CONNEXIN-26; MISSENSE MUTATION;
D O I：
10.1152/physiol.00058.2012
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
In the present review, we provide an overview of connexin expression during skin development and remodeling in wound healing, and reflect on how loss- or gain-of-function connexin mutations may change cellular phenotypes and lead to diseases of the skin. We also consider the therapeutic value of targeting connexins in wound healing.
引用
收藏
页码：190 / 198
页数：9
相关论文
共 81 条
[1]   Transfer of biologically important molecules between cells through gap junction channels [J].
Alexander, DB ;
Goldberg, GS .
CURRENT MEDICINAL CHEMISTRY, 2003, 10 (19) :2045-2058
[2]   Gap junction development in the human fetal hair follicle and bulge region [J].
Arita, K ;
Akiyama, M ;
Tsuji, Y ;
McMillan, JR ;
Eady, RAJ ;
Shimizu, H .
BRITISH JOURNAL OF DERMATOLOGY, 2004, 150 (03) :429-434
[3]   Targeting connexin 43 in diabetic wound healing: Future perspectives [J].
Bajpai, S. ;
Shukla, V. K. ;
Tripathi, K. ;
Srikrishna, S. ;
Singh, R. K. .
JOURNAL OF POSTGRADUATE MEDICINE, 2009, 55 (02) :143-149
[4]   Targeted epidermal expression of mutant Connexin 26(D66H) mimics true Vohwinkel syndrome and provides a model for the pathogenesis of dominant connexin disorders [J].
Bakirtzis, G ;
Choudhry, R ;
Aasen, T ;
Shore, L ;
Brown, K ;
Bryson, S ;
Forrow, S ;
Tetley, L ;
Finbow, M ;
Greenhalgh, D ;
Hodgins, M .
HUMAN MOLECULAR GENETICS, 2003, 12 (14) :1737-1744
[5]   The effects of a mutant connexin 26 on epidermal differentiation [J].
Bakirtzis, G ;
Jamieson, S ;
Aasen, T ;
Bryson, S ;
Forrow, S ;
Tetley, L ;
Finbow, M ;
Greenhalgh, D ;
Hodgins, M .
CELL COMMUNICATION AND ADHESION, 2003, 10 (4-6) :359-364
[6]   Connexins 26, 30, and 43:: Differences among spontaneous, chronic, and accelerated human wound healing [J].
Brandner, JM ;
Houdek, P ;
Hüsing, B ;
Kaiser, C ;
Moll, I .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2004, 122 (05) :1310-1320
[7]   SWITCH IN GAP JUNCTION PROTEIN EXPRESSION IS ASSOCIATED WITH SELECTIVE CHANGES IN JUNCTIONAL PERMEABILITY DURING KERATINOCYTE DIFFERENTIATION [J].
BRISSETTE, JL ;
KUMAR, NM ;
GILULA, NB ;
HALL, JE ;
DOTTO, GP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (14) :6453-6457
[8]  
BUTTERWECK A, 1994, EUR J CELL BIOL, V65, P152
[9]  
Choudhry R, 1997, DEV DYNAM, V210, P417, DOI 10.1002/(SICI)1097-0177(199712)210:4<417::AID-AJA6>3.0.CO
[10]  
2-J
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