Bioactive Glass-Based Scaffolds for Bone Tissue Engineering

被引：52

作者：

Will, Julia ^{[1
]}

Gerhardt, Lutz-Christian ^{[2
]}

Boccaccini, Aldo R. ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Dept Mat Sci & Engn, Inst Biomat, D-91058 Erlangen, Germany

[2] Tech Univ Eindhoven, NL-5600 MB Eindhoven, Netherlands

来源：

TISSUE ENGINEERING III: CELL-SURFACE INTERACTIONS FOR TISSUE CULTURE | 2012年 / 126卷

关键词：

Bioactive glasses; Scaffolds; Bone tissue engineering; Angiogenesis; OSTEOBLAST-LIKE CELLS; PHYSIOLOGICALLY-BASED MODELS; IN-VITRO CHARACTERIZATION; ANGIOGENIC GROWTH-FACTORS; COMPOSITE FOAM SCAFFOLDS; ANNULUS FIBROSUS CELLS; CERAMIC SCAFFOLDS; MECHANICAL-PROPERTIES; ORIENTED MICROSTRUCTURES; BIOMEDICAL APPLICATIONS;

D O I：

10.1007/10_2011_106

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Originally developed to fill and restore bone defects, bioactive glasses are currently also being intensively investigated for bone tissue engineering applications. In this chapter, we review and discuss current knowledge on porous bone tissue engineering scaffolds made from bioactive silicate glasses. A brief historical review and the fundamental requirements in the field of bone tissue engineering scaffolds will be presented, followed by a detailed overview of recent developments in bioactive glass-based scaffolds. In addition, the effects of ionic dissolution products of bioactive glasses on osteogenesis and angiogenic properties of scaffolds are briefly addressed. Finally, promising areas of future research and requirements for the advancement of the field are highlighted and discussed.

引用

页码：195 / 226

页数：32

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