In Vitro Activity of Daclatasvir on Hepatitis C Virus Genotype 3 NS5A

被引：44
作者：
Wang, Chunfu [1 ]
Valera, Lourdes [1 ]
Jia, Lingling [1 ]
Kirk, Melissa J. [1 ]
Gao, Min [1 ]
Fridell, Robert A. [1 ]
机构：
[1] Bristol Myers Squibb Co, Dept Virol, Res & Dev, Wallingford, CT 06492 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2013年 / 57卷 / 01期
关键词：
REPLICATION COMPLEX INHIBITOR; BMS-790052; REPLICON; RESISTANCE;
D O I：
10.1128/AAC.01874-12
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The NS5A replication complex inhibitor daclatasvir (DCV; BMS-790052) inhibits hybrid replicons containing hepatitis C virus (HCV) genotype 3a (HCV3a) NS5A genes with 50% effective concentrations (EC(50)s) ranging from 120 to 870 pM. Selection studies with a hybrid HCV3a replicon identified NS5A residues 31 and 93 as sites for DCV-selected resistance. Our results support the potential use of DCV as a component in combination therapies for HCV3a chronic infection.
引用
收藏
页码：611 / 613
页数：3
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