PHARMACOLOGIC INHIBITION OF DGKα ACTIVATES T CELLS AND ENHANCES ANTI-TUMOR IMMUNITY

被引：0
|
作者：
Wang, Adele [1 ]
Stapleton, Lance [1 ]
Belzie, Jean-Philippe [1 ]
Xing, Weimei [1 ]
Muiru, Gladys [1 ]
Kornyeyev, Dmytro [1 ]
Hsieh, Edward [1 ]
Liclican, Albert [1 ]
Toy, Pamela [1 ]
Xu, Mengshu [1 ]
Kim, Kei [1 ]
Lee, Jacob [1 ]
Kuhne, Michelle [1 ]
Lad, Latesh [1 ]
机构：
[1] Gilead Sci Inc, Foster City, CA USA
来源：
JOURNAL FOR IMMUNOTHERAPY OF CANCER | 2022年 / 10卷
关键词：
D O I：
10.1136/jitc-2022-SITC2022.1066
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
1066
引用
收藏
页码：A1108 / A1108
页数：1
相关论文
共 50 条
  • [1] Pharmacologic modulation of RNA splicing enhances anti-tumor immunity
    Lu, Sydney X.
    De Neef, Emma
    Thomas, James D.
    Sabio, Erich
    Rousseau, Benoit
    Gigoux, Mathieu
    Knorr, David A.
    Greenbaum, Benjamin
    Elhanati, Yuval
    Hogg, Simon J.
    Chow, Andrew
    Ghosh, Arnab
    Xie, Abigail
    Zamarin, Dmitriy
    Cui, Daniel
    Erickson, Caroline
    Singer, Michael
    Cho, Hana
    Wang, Eric
    Lu, Bin
    Durham, Benjamin H.
    Shah, Harshal
    Chowell, Diego
    Gabel, Austin M.
    Shen, Yudao
    Liu, Jing
    Jin, Jian
    Rhodes, Matthew C.
    Taylor, Richard E.
    Molina, Henrik
    Wolchok, Jedd D.
    Merghoub, Taha
    Diaz, Luis A., Jr.
    Abdel-Wahab, Omar
    Bradley, Robert K.
    CELL, 2021, 184 (15) : 4032 - +
  • [2] Pharmacologic modulation of RNA splicing enhances anti-tumor immunity
    Thomas, James D.
    Lu, Sydney X.
    De Neef, Emma
    Sabio, Erich
    Rousseau, Benoit
    Gigoux, Mathieu
    Knorr, David A.
    Greenbaum, Benjamin
    Elhanati, Yuval
    Hogg, Simon J.
    Chow, Andrew
    Ghosh, Arnab
    Xie, Abigail
    Zamarin, Dmitriy
    Cui, Daniel
    Erickson, Caroline
    Singer, Michael
    Cho, Hana
    Wang, Eric
    Lu, Bin
    Durham, Benjamin H.
    Shah, Harshal
    Chowell, Diego
    Gabel, Austin M.
    Shen, Yudao
    Liu, Jing
    Jin, Jian
    Rhodes, Matthew C.
    Taylor, Richard E.
    Molina, Henrik
    Wolchok, Jedd D.
    Merghoub, Taha
    Diaz, Luis A., Jr.
    Abdel-Wahab, Omar
    Bradley, Robert K.
    CANCER RESEARCH, 2023, 83 (07)
  • [3] Targeting tumor cells with antibodies enhances anti-tumor immunity
    Zhichen Sun
    Yang-Xin Fu
    Hua Peng
    Biophysics Reports, 2018, 4 (05) : 243 - 253
  • [4] Inhibition of acetate metabolism enhances host anti-tumor immunity
    Miller, Katelyn
    Schug, Zachary T.
    CANCER RESEARCH, 2021, 81 (04)
  • [5] Tozasertib activates anti-tumor immunity through decreasing regulatory T cells in melanoma
    Wang, Qiaoling
    Liu, Wuyi
    Zhou, Huyue
    Lai, Wenjing
    Hu, Changpeng
    Dai, Yue
    Li, Guobing
    Zhang, Rong
    Zhao, Yu
    NEOPLASIA, 2024, 48
  • [6] Sirt2 inhibition enhances anti-tumor immunity by promoting T cell metabolism
    Hamaidi, Imene
    Zhang, Lin
    Kim, Nayoung
    Wang, Min-Hsuan
    Iclozan, Cristina
    Fang, Bin
    Liu, Min
    Koomen, John
    Berglund, Anders
    Yoder, Sean
    Yao, Jiqiang
    Creelan, Ben
    Antonia, Scott
    Kim, Sungjune
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2019, 7
  • [7] Inhibition of the Wnt/β-catenin pathway enhances anti-tumor immunity in ovarian cancer
    Doo, D. W.
    Meza-Perez, S.
    Londono, A.
    Boone, J. D.
    Moore, D. J.
    Hudson, C.
    Betella, I.
    Luke, J. J.
    Yang, E. S.
    Birrer, M. J.
    Starenki, D.
    Buchsbaum, D. J.
    Norian, L. A.
    Randall, T.
    Arend, R. C.
    GYNECOLOGIC ONCOLOGY, 2019, 154 : 95 - 95
  • [8] Targeting Macrophages with CAR-T Cells Delays Solid Tumor Progression and Enhances Anti-Tumor Immunity
    Sanchez-Paulete, Alfonso R.
    Mateus-Tique, Jaime
    Mollaoglu, Gurkan
    Nielsen, Sebastian R.
    Marks, Adam
    Lakshmi, Ashwitha
    Pia, Luisanna
    Baccarini, Alessia
    Merad, Miriam
    Brown, Brian D.
    MOLECULAR THERAPY, 2022, 30 (04) : 317 - 317
  • [9] Pharmacologic inhibition of liver X receptors enhances T cell anti-tumor function in triple negative breast cancer
    Carpenter, Katherine Joyce
    Abuirqeba, Suomia
    Majidi, Shabnam
    Sengupta, Monideepa
    Valfort, Aurore-Cecile
    Chatterjee, Arindam
    DiPaolo, Richard J.
    Flaveny, Colin A.
    JOURNAL OF IMMUNOLOGY, 2019, 202 (01):
  • [10] Function of T follicular helper cells in anti-tumor immunity
    Nurieva, Roza I.
    Liu, Zhongshan
    Gangadharan, Achintyan
    Bieerkehazhi, Shayahati
    Zhao, Yang-Zhi
    Alekseev, Andrei
    Sahoo, Anupama
    JOURNAL OF IMMUNOLOGY, 2019, 202 (01):
12345