The Complex Function of Hsp70 in Metastatic Cancer

被引：72
作者：
Juhasz, Kata [1 ]
Lipp, Anna-Maria [1 ]
Nimmervoll, Benedikt [1 ]
Sonnleitner, Alois [1 ]
Hesse, Jan [1 ]
Haselgruebler, Thomas [1 ]
Balogi, Zsolt [1 ]
机构：
[1] Ctr Adv Bioanalysis GmbH, Gruberstr 40-42, A-4020 Linz, Austria
来源：
CANCERS | 2014年 / 6卷 / 01期
关键词：
Hsp70; metastasis; invasion; trafficking; lysosome; HEAT-SHOCK-PROTEIN; HEAT-SHOCK-PROTEIN-70 PEPTIDE COMPLEXES; EPITHELIAL-MESENCHYMAL TRANSITION; SEVERE COMBINED IMMUNODEFICIENCY; CELL-SURFACE EXPRESSION; NATURAL-KILLER-CELLS; TUMOR-CELLS; EXTRACELLULAR HSP70; CARCINOMA-CELLS; MOLECULAR CHAPERONES;
D O I：
10.3390/cancers6010042
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Elevated expression of the inducible heat shock protein 70 ( Hsp70) is known to correlate with poor prognosis in many cancers. Hsp70 confers survival advantage as well as resistance to chemotherapeutic agents, and promotes tumor cell invasion. At the same time, tumor-derived extracellular Hsp70 has been recognized as a "chaperokine", activating antitumor immunity. In this review we discuss localization dependent functions of Hsp70 in the context of invasive cancer. Understanding the molecular principles of metastasis formation steps, as well as interactions of the tumor cells with the microenvironment and the immune system is essential for fighting metastatic cancer. Although Hsp70 has been implicated in different steps of the metastatic process, the exact mechanisms of its action remain to be explored. Known and potential functions of Hsp70 in controlling or modulating of invasion and metastasis are discussed.
引用
收藏
页码：42 / 66
页数：25
相关论文
共 207 条
  • [41] Involvement of heat shock protein-70 in the mechanism of hydrogen peroxide-induced DNA damage: The role of lysosomes and iron
    Doulias, Paschalis-Thomas
    Kotoglou, Polychronis
    Tenopoulou, Margarita
    Keramisanou, Dimitra
    Tzavaras, Theodore
    Brunk, Ulf
    Galaris, Dimitrios
    Angelidis, Charalampos
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 2007, 42 (04) : 567 - 577
  • [42] Silencing of Heat Shock Protein 70 Expression Enhances Radiotherapy Efficacy and Inhibits Cell Invasion in Endometrial Cancer Cell Line
    Du, Xue-Lian
    Jiang, Tao
    Wen, Ze-Qing
    Gao, Rong
    Cui, Min
    Wang, Fei
    [J]. CROATIAN MEDICAL JOURNAL, 2009, 50 (02) : 143 - 150
  • [43] MAP KINASE ACTIVATION DURING HEAT-SHOCK IN QUIESCENT AND EXPONENTIALLY GROWING MAMMALIAN-CELLS
    DUBOIS, MF
    BENSAUDE, O
    [J]. FEBS LETTERS, 1993, 324 (02): : 191 - 195
  • [44] Ellerbroek SM, 1998, INT J CANCER, V78, P331, DOI 10.1002/(SICI)1097-0215(19981029)78:3<331::AID-IJC13>3.0.CO
  • [45] 2-9
  • [46] Masquerader: High mobility group box-1 and cancer
    Ellerman, Jessica E.
    Brown, Charles K.
    de Vera, Michael
    Zeh, Herbert J.
    Billiar, Timothy
    Rubartelli, Anna
    Lotze, Michael T.
    [J]. CLINICAL CANCER RESEARCH, 2007, 13 (10) : 2836 - 2848
  • [47] Enhanced immunogenicity of heat shock protein 70 peptide complexes from dendritic cell-tumor fusion cells
    Enomoto, Yutaka
    Bharti, Ajit
    Khaleque, Ad Abdul
    Song, Baizheng
    Liu, Chunlei
    Apostolopoulos, Vasso
    Xing, Pei-xiang
    Calderwood, Stuart K.
    Gong, Jianlin
    [J]. JOURNAL OF IMMUNOLOGY, 2006, 177 (09) : 5946 - 5955
  • [48] Extracellular Hsp70 stimulates multiple signaling pathways in A431 carcinoma cells
    Evdonin A.L.
    Kropacheva I.V.
    Medvedeva N.D.
    [J]. Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology, 2009, 3 (3) : 291 - 297
  • [49] Extracellular heat shock protein 70 mediates heat stress-induced epidermal growth factor receptor transactivation in A431 carcinoma cells
    Evdonin, Anton L.
    Guzhova, Irina V.
    Margulis, Boris A.
    Medvedeva, Natalia D.
    [J]. FEBS LETTERS, 2006, 580 (28-29) : 6674 - 6678
  • [50] Lysosornes as targets for cancer therapy
    Fehrenbacher, N
    Jäättelä, M
    [J]. CANCER RESEARCH, 2005, 65 (08) : 2993 - 2995
12345678910