Interaction of flurbiprofen sodium with cornea model monolayers at the air-water interface

被引：5
|
作者：
Garcia, ML [1 ]
Egea, MA [1 ]
Valero, J [1 ]
Valls, O [1 ]
Alsina, MA [1 ]
机构：
[1] UNIV BARCELONA,FAC PHARM,PHYSICOCHEM UNITY,E-08028 BARCELONA,SPAIN
来源：
THIN SOLID FILMS | 1997年 / 301卷 / 1-2期
关键词：
cornea membrane model; flurbiprofen sodium; compression isotherms; penetration kinetics;
D O I：
10.1016/S0040-6090(96)09589-2
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
In this work cornea lipid model monolayers, at the air-water interface, containing different percentages of cholesterol were developed. The different membrane models were characterized by the compression isotherms, compressibility and area per molecule values. The influence of cholesterol variations on the interaction of flurbiprofen sodium with the lipid monolayers was also studied, by penetration kinetics of the drug into the monolayers at different initial surface pressures (5, 10 and 20 mN m(-1)). The results obtained suggest that the cholesterol content is a factor to consider in the interaction of flurbiprofen sodium with the cornea models.
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页码：169 / 174
页数：6
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