GRGDS-Functionalized Poly(lactide)-graft-poly(ethylene glycol) Copolymers: Combining Thiol-Ene Chemistry with Staudinger Ligation

被引：40

作者：

Borchmann, Dorothee E.

ten Brummelhuis, Niels

Weck, Marcus ^{[1
]}

机构：

[1] NYU, Inst Mol Design, New York, NY 10003 USA

来源：

MACROMOLECULES | 2013年 / 46卷 / 11期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

AZIDE; CYCLOADDITION; NANOPARTICLES; POLYMERS;

D O I：

10.1021/ma4005633

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A tri(ethylene glycol)-containing lactide analogue was synthesized via thiol-ene chemistry between a bifunctional triethylene glycol and allyl lactide. Subsequent tin octoate catalyzed ring opening polymerization yielded well poly(lactide)-graft-poly(ethylene glycol) copolymers with molecular weights of 6 x 10(3) g/mol and polydispersity indices of 1.6. The tri(ethylene glycol) chains along the copolymers contain azide termini that are capable of efficient postpolymerization functionalization. The utility of this strategy was demonstrated via successful Staudinger ligation to install the Gly-Arg-Gly-Asp-Ser (GRGDS) peptide.

引用

页码：4426 / 4431

页数：6

共 29 条

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