Versicolols A and B, two new prenylated isocoumarins from endophytic fungus Aspergillus versicolor and their cytotoxic activity

被引：24

作者：

Zhou, Min ^{[1
,2
]}

Lou, Jie ^{[1
,2
]}

Li, Yin-Ke ^{[3
]}

Wang, Yue-De ^{[1
,2
]}

Zhou, Kun ^{[1
,2
]}

Ji, Bing-Kun ^{[1
,2
]}

Dong, Wei ^{[1
,2
]}

Gao, Xue-Mei ^{[1
,2
]}

Du, Gang ^{[1
,2
]}

Hu, Qiu-Fen ^{[1
,2
]}

机构：

[1] Yunnan Minzu Univ, Key Lab Chem Ethn Med Resources, State Ethn Affairs Commiss, Kunming 650031, Peoples R China

[2] Yunnan Minzu Univ, Minist Educ, Kunming 650031, Peoples R China

[3] Yuxi Normal Univ, Coll Resource & Environm, Yuxi 653100, Peoples R China

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2017年 / 40卷 / 01期

关键词：

Prenylated isocoumarins; Aspergillus versicolor; Cytotoxicity; DERIVATIVES; METABOLITES;

D O I：

10.1007/s12272-015-0588-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Versicolols A and B (1 and 2), two rare prenylated isocoumarin derivatives, along with five known isocoumarins (3-7) were isolated from the fermentation products of an endophytic fungus Aspergillus versicolor. Their structures were elucidated on the basis of extensive spectroscopic analysis, including 1D- and 2D-NMR techniques. Compounds 1 and 2 were evaluated for their cytotoxicity against five human tumor cell lines. The results showed that compounds 1 exhibited weak cytotoxicity against A549 and MCF7 cells with IC50 values of 9.4 and 8.8 mu m, and compound 2 exhibited weak cytotoxicity against SHSY5Y and MCF7 cells with IC50 values of 8.2 and 6.8 mu m, respectively.

引用

页码：32 / 36

页数：5

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