Versicolols A and B, two new prenylated isocoumarins from endophytic fungus Aspergillus versicolor and their cytotoxic activity

被引：23
|
作者：
Zhou, Min [1 ,2 ]
Lou, Jie [1 ,2 ]
Li, Yin-Ke [3 ]
Wang, Yue-De [1 ,2 ]
Zhou, Kun [1 ,2 ]
Ji, Bing-Kun [1 ,2 ]
Dong, Wei [1 ,2 ]
Gao, Xue-Mei [1 ,2 ]
Du, Gang [1 ,2 ]
Hu, Qiu-Fen [1 ,2 ]
机构：
[1] Yunnan Minzu Univ, Key Lab Chem Ethn Med Resources, State Ethn Affairs Commiss, Kunming 650031, Peoples R China
[2] Yunnan Minzu Univ, Minist Educ, Kunming 650031, Peoples R China
[3] Yuxi Normal Univ, Coll Resource & Environm, Yuxi 653100, Peoples R China
来源：
ARCHIVES OF PHARMACAL RESEARCH | 2017年 / 40卷 / 01期
关键词：
Prenylated isocoumarins; Aspergillus versicolor; Cytotoxicity; DERIVATIVES; METABOLITES;
D O I：
10.1007/s12272-015-0588-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Versicolols A and B (1 and 2), two rare prenylated isocoumarin derivatives, along with five known isocoumarins (3-7) were isolated from the fermentation products of an endophytic fungus Aspergillus versicolor. Their structures were elucidated on the basis of extensive spectroscopic analysis, including 1D- and 2D-NMR techniques. Compounds 1 and 2 were evaluated for their cytotoxicity against five human tumor cell lines. The results showed that compounds 1 exhibited weak cytotoxicity against A549 and MCF7 cells with IC50 values of 9.4 and 8.8 mu m, and compound 2 exhibited weak cytotoxicity against SHSY5Y and MCF7 cells with IC50 values of 8.2 and 6.8 mu m, respectively.
引用
收藏
页码：32 / 36
页数：5
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