High-yield synthesis of a chiroporphyrin by hydrogen bond-directed cyclisation

被引：5
|
作者：
Pérollier, C
Pécaut, J
Ramasseul, R
Bau, R
Marchon, JC [1 ]
机构：
[1] CEA, Dept Rech Fondamentale Mat Condensee, Serv Chim Inorgan & Biol, Chim Coordinat Lab, F-38054 Grenoble, France
[2] Univ So Calif, Dept Chem, Los Angeles, CA 90089 USA
来源：
CHEMICAL COMMUNICATIONS | 1999年 / 16期
关键词：
D O I：
10.1039/a904134f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new chiroporphyrin is prepared in 60% yield using complementary intramolecular hydrogen-bonding interactions between N-acylurea substituents to direct the cyclisation of the tetrapyrrolic intermediate; similar hydrogen-bond assistance by carboxylic acid functions is suggested for cyclisation of hydroxymethylbilane to uroporphyrinogen I.
引用
收藏
页码：1597 / 1598
页数：2
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