Irbesartan Attenuates Sepsis-Induced Renal Injury In Mice Models.

Sepsis is the main cause of death following infection and is regarded as a worldwide health problem. Sepsis is a systemic inflammatory side consequence of microbial infection. To investigate any possible reno-protective effects of irbesartan during sepsis-induced renal damage. Forty male albino Swiss mice, weighing 25-30 grams and aged 8-12 weeks, were used in the current investigation. Both food and water were freely available to these animals. Mice were separated into the following four groups after two weeks of adaption. (n = 10): (1) Normal group: apparently healthy mice. (2) CLP group: mice underwent CLP operation. (3) Vehicle group: mice received DMSO (4) irbesartan group: mice received irbesartan 3 mg/kg/day intraperitoneally for 5 consecutive days. ) irbesartan group demonstrated a significant (p<0.05) decrease in the renal levels of NGAL as compared to the CLP group. Furthermore, the irbesartan group demonstrated a significant (p<0.05) decrease in the serum level of inflammatory cytokines (TNF-alpha, IL-6, & IL -113) as compared to the CLP group. Additionally, the irbesartan group showed a significant (p<0.05) elevation in the renal SOD activity and reduction of MDA level as compared to the CLP group. Histologically, All mice in the CLP group showed a significant (p<0.05) renal tissue injury, while the irbesartan group showed a significant (p<0.05) reduced level of renal tissue injury. The anti-inflammatory effect through their ability to decrease serum levels of inflammatory cytokines (TNF-alpha, IL -113, and IL-6). Also the anti-oxidant effect through their ability to decrease renal levels of MDA and increase the renal activity of SOD.