Photosensitization and mutation induced in Escherichia coli and Saccharomyces cerevisiae strains by dorstenin, a psoralen analog isolated from Dorstenia bahiensis

被引：5

作者：

Lopes, D

Oliveira, RR

Kaplan, MAC

Lage, CS

Leitao, AC

机构：

[1] Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, BR-2149900 Rio De Janeiro, Brazil

[2] EMBRAPA Agroind Alimentos, Rio De Janeiro, Brazil

[3] Univ Fed Rio de Janeiro, Nucleo Pesquisas Prod Nat, Rio De Janeiro, Brazil

来源：

PLANTA MEDICA | 2001年 / 67卷 / 09期

关键词：

Dorstenia; Moraceae; photosensitization; mutation; dorstenin; Escherichia coli; Saccharomyces cerevisiae;

D O I：

10.1055/s-2001-18858

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Dorstenin, 5-[3-(4,5-dihydro-5,5-dimethyl-4-oxo-2-furanyl)-butoxy]-7H-furo[3, 2-g] (1) benzopyran-7-one, is a psoralen analog recently isolated from Dorstenia species (Moraceae). In order to characterize its biological activity, its photosensitizing and mutational properties were measured in wild-type E. coli and S. cerevisiae and also in strains carrying mutations which affect DNA repair. Compared to the high activities of psoralen and bergapten, dorstenin showed lower genotoxic effect.

引用

页码：820 / 824

页数：5

共 12 条

[1] CONVERSION OF PSORALEN DNA MONOADDUCTS IN ESCHERICHIA-COLI TO INTER-STRAND DNA CROSS LINKS BY NEAR UV LIGHT (320-360 NM) - INABILITY OF ANGELICIN TO FORM CROSS LINKS, INVIVO [J].