Ovarian development in mice requires the GATA4-FOG2 transcription complex

被引：74
作者：
Manuylov, Nikolay L. [1 ]
Smagulova, Fatima O. [1 ]
Leach, Lyndsay [1 ]
Tevosian, Sergei G. [1 ]
机构：
[1] Dartmouth Med Sch, Dept Genet, Hanover, NH 03755 USA
来源：
DEVELOPMENT | 2008年 / 135卷 / 22期
基金：
美国国家卫生研究院;
关键词：
Fog2 (Zfpm2); Gata4; Dkk1; Ovary; beta-catenin; Mouse;
D O I：
10.1242/dev.024653
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We have demonstrated previously that mammalian sexual differentiation requires both the GATA4 and FOG2 transcriptional regulators to assemble the functioning testis. Here we have determined that the sexual development of female mice is profoundly affected by the loss of GATA4-FOG2 interaction. We have also identified the Dkk1 gene, which encodes a secreted inhibitor of canonical beta-catenin signaling, as a target of GATA4-FOG2 repression in the developing ovary. The tissue-specific ablation of the beta-catenin gene in the gonads disrupts female development. In Gata4(ki/ki); Dkk1(-/-) or Fog2(-/-); Dkk1(-/)- embryos, the normal ovarian gene expression pattern is partially restored. Control of ovarian development by the GATA4-FOG2 complex presents a novel insight into the cross-talk between transcriptional regulation and extracellular signaling that occurs in ovarian development.
引用
收藏
页码：3731 / 3743
页数：13
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