Memory Upgrade: Insights into Primed Adaptation by CRISPR-Cas Immune Systems

被引：2
作者：
Ramachandran, Anita [1 ]
Bailey, Scott [1 ,2 ]
机构：
[1] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Biochem & Mol Biol, Baltimore, MD 21205 USA
[2] Johns Hopkins Univ, Sch Med, Dept Biophys & Biophys Chem, Baltimore, MD 21205 USA
来源：
MOLECULAR CELL | 2016年 / 64卷 / 04期
关键词：
SPACER ACQUISITION; ADAPTIVE IMMUNITY; FOREIGN DNA; COLI; COMPLEX;
D O I：
10.1016/j.molcel.2016.11.008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recently, Kunne et al. (2016) demonstrated that degradation products of Cas3 obtained during CRISPR interference fuel priming. In this issue of Molecular Cell, Xue et al. (2016) highlight the conformational changes in Cascade that underpin the priming process when interference is blocked.
引用
收藏
页码：641 / 642
页数：2
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