Association of+331G/A PgR Polymorphism with Susceptibility to Female Reproductive Cancer: Evidence from a Meta-Analysis

被引：16

作者：

Chaudhary, Sanjib ^{[1
]}

Panda, Aditya K. ^{[2
]}

Mishra, Dipti Ranjan ^{[1
]}

Mishra, Sandip K. ^{[1
]}

机构：

[1] Inst Life Sci, Dept Gene Funct & Regulat, Canc Biol Lab, Bhubaneswar, Orissa, India

[2] Inst Life Sci, Dept Infect Dis Biol, Bhubaneswar, Orissa, India

来源：

PLOS ONE | 2013年 / 8卷 / 01期

关键词：

PROGESTERONE-RECEPTOR GENE; BREAST-CANCER; ENDOMETRIAL CANCER; HORMONE-THERAPY; RISK; OVARIAN; ESTROGEN; EXPRESSION; PROMOTER; METABOLISM;

D O I：

10.1371/journal.pone.0053308

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The progesterone receptor (PgR), a sex steroid hormone receptor that binds progesterone is critical for normal breast development. The PgR (+331G/A, rs10895068) promoter polymorphism is associated with cancer risk possibly by altering the expression of progesterone receptor B isoform. Previous studies have provided inconsistent results. To validate the association between the PgR +331G/A polymorphism and female reproductive cancer risk (breast, endometrial and ovarian cancer), we performed a meta-analysis of 19 studies (19,978 cases and 24,525 controls) by using the CMA Version 2 software. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the associations. The overall results indicated that the variant allele and genotypes were associated with a mild increase in overall female reproductive cancer risk (A vs. G: OR = 1.063, 95% CI = 1.001-1.129; AA+AG vs. GG: OR = 1.067, 95% CI = 1.002-1.136). The results suggest that the PgR +331G/A polymorphism might be associated with an increased female reproductive cancer risk.

引用

页数：7

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