Sinusoidal endothelial cells are damaged and display enhanced autophagy in myelodysplastic syndromes

被引:6
作者
Houwerzijl, Ewout J. [1 ]
van den Heuvel, Fiona A. J. [2 ,3 ]
Blom, Nel R. [2 ,3 ]
van der Want, Johannes J. L. [4 ]
Mulder, Andre B. [3 ]
Vellenga, Edo [2 ]
机构
[1] Univ Groningen, Univ Med Ctr Groningen, Dept Vasc Med, NL-9713 AV Groningen, Netherlands
[2] Univ Groningen, Univ Med Ctr Groningen, Dept Haematol, NL-9713 AV Groningen, Netherlands
[3] Univ Groningen, Univ Med Ctr Groningen, NL-9713 AV Groningen, Netherlands
[4] Univ Groningen, Univ Med Ctr Groningen, Dept Cell Biol, NL-9713 AV Groningen, Netherlands
关键词
MDS; endothelial cells; electron microscopy; HUMAN BONE-MARROW;
D O I
10.1111/bjh.12227
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页码:443 / 446
页数:4
相关论文
共 10 条
[1]   Ontogenic emergence of the hematon, a morphogenetic stromal unit that supports multipotential hematopoietic progenitors in mouse bone marrow [J].
Blazsek, I ;
Chagraoui, J ;
Péault, B .
BLOOD, 2000, 96 (12) :3763-3771
[2]   Immunophenotypic, cytogenetic and functional characterization of circulating endothelial cells in myelodysplastic syndromes [J].
Della Porta, M. G. ;
Malcovati, L. ;
Rigolin, G. M. ;
Rosti, V. ;
Bonetti, E. ;
Travaglino, E. ;
Boveri, E. ;
Galli, A. ;
Boggi, S. ;
Ciccone, M. ;
Pramparo, T. ;
Mazzini, G. ;
Invernizzi, R. ;
Lazzarino, M. ;
Cazzola, M. .
LEUKEMIA, 2008, 22 (03) :530-537
[3]   The vascular niche: home for normal and malignant hematopoietic stem cells [J].
Doan, P. L. ;
Chute, J. P. .
LEUKEMIA, 2012, 26 (01) :54-62
[4]   Erythroid precursors from patients with low-risk myelodysplasia demonstrate ultrastructural features of enhanced autophagy of mitochondria [J].
Houwerzijl, E. J. ;
Pol, H-W D. ;
Blom, N. R. ;
van der Want, J. J. L. ;
de Wolf, J. Thm ;
Vellenga, E. .
LEUKEMIA, 2009, 23 (05) :886-891
[5]   The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage [J].
Lancrin, Christophe ;
Sroczynska, Patrycja ;
Stephenson, Catherine ;
Allen, Terry ;
Kouskoff, Valerie ;
Lacaud, Georges .
NATURE, 2009, 457 (7231) :892-895
[6]   Basic and Therapeutic Aspects of Angiogenesis [J].
Potente, Michael ;
Gerhardt, Holger ;
Carmeliet, Peter .
CELL, 2011, 146 (06) :873-887
[7]   Differentiation and expansion of endothelial cells from human bone marrow CD133+ cells [J].
Quirici, N ;
Soligo, D ;
Caneva, L ;
Servida, F ;
Bossolasco, P ;
Deliliers, GL .
BRITISH JOURNAL OF HAEMATOLOGY, 2001, 115 (01) :186-194
[8]   Endothelial progenitor cell infusion induces hematopoietic stem cell reconstitution in vivo [J].
Salter, Alice B. ;
Meadows, Sarah K. ;
Muramoto, Garrett G. ;
Himburg, Heather ;
Doan, Phuong ;
Daher, Pamela ;
Russell, Lauren ;
Chen, Benny ;
Chao, Nelson J. ;
Chute, John P. .
BLOOD, 2009, 113 (09) :2104-2107
[9]   MARROW-BLOOD BARRIER [J].
TAVASSOLI, M .
BRITISH JOURNAL OF HAEMATOLOGY, 1979, 41 (03) :297-302
[10]  
WICKRAMASINGHE SN, 1991, CLIN LAB HAEMATOL, V13, P263