Gold nanoparticles in radiation research: potential applications for imaging and radiosensitization

被引：76

作者：

Dorsey, Jay F. ^{[1
]}

Sun, Lova ^{[1
]}

Joh, Daniel Y. ^{[1
]}

Witztum, Alon ^{[1
]}

Al Zaki, Ajlan ^{[2
]}

Kao, Gary D. ^{[1
]}

Alonso-Basanta, Michelle ^{[1
]}

Avery, Stephen ^{[1
]}

Tsourkas, Andrew ^{[2
]}

Hahn, Stephen M. ^{[1
]}

机构：

[1] Univ Penn, Perelman Sch Med, Dept Radiat Oncol, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA

来源：

TRANSLATIONAL CANCER RESEARCH | 2013年 / 2卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Gold Nanoparticle (GNP); theranostics; radiosensitization; nanoscale; RAY COMPUTED-TOMOGRAPHY; IN-VIVO; CONTRAST AGENTS; CANCER-CELLS; ENHANCEMENT; SIZE; CYTOTOXICITY; RADIOTHERAPY; RECEPTOR; BIODISTRIBUTION;

D O I：

10.3978/j.issn.2218-676X.2013.08.09

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The potential of gold nanoparticles (GNPs) in therapeutic and diagnostic cancer applications is becoming increasingly recognized. These biologically compatible particles can be easily synthesized, tuned to different sizes, and functionalized by conjugation to various biologically useful materials. Efficient and specific delivery to tumor tissue can then be accomplished either by passive accumulation in leaky tumor vessels and tissue, or by directly targeting tumor-specific biomarkers. Tumor-localized GNPs can serve as both adjuvants for enhancing the efficacy of radiation therapy and also as contrast agents for various imaging modalities. In this review, we will discuss recent advancements and future potential in the application of GNP as both a radiosensitizer and an imaging contrast agent. Due to their versatility and biocompatibility, gold nanoparticles may represent a novel theranostic adjuvant for radiation applications in cancer management.

引用

页码：280 / 291

页数：12

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