Therapeutic Controversies in Spondyloarthritis Nonsteroidal Anti-Inflammatory Drugs

被引:20
作者
Poddubnyy, Denis [1 ]
van der Heijde, Desiree [2 ]
机构
[1] Charite, Dept Med 1, D-12203 Berlin, Germany
[2] Leiden Univ, Med Ctr, Dept Rheumatol, NL-2300 RC Leiden, Netherlands
关键词
Spondyloarthritis; Ankylosing spondylitis; ASAS; Nonsteroidal anti-inflammatory drugs; Therapy; ACTIVE ANKYLOSING-SPONDYLITIS; RANDOMIZED CONTROLLED-TRIAL; OPEN-LABEL TRIAL; AXIAL SPONDYLOARTHRITIS; RADIOGRAPHIC PROGRESSION; ASAS/EULAR RECOMMENDATIONS; RHEUMATOID-ARTHRITIS; ASAS RECOMMENDATIONS; ULCER COMPLICATIONS; SPINAL MOBILITY;
D O I
10.1016/j.rdc.2012.08.005
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Nonsteroidal anti-inflammatory drugs (NSAIDs) are considered a first-line therapy in patients with axial spondyloarthritis (axSpA), including ankylosing spondylitis. NSAIDs reduce pain and stiffness effectively in most patients, are able to reduce systemic and local inflammation, and can inhibit progression of structural damage in the spine. However, effective control of symptoms and retardation of radiographic progression often require continuous and long-term treatment, which raises safety concerns. This article discusses controversies related to the current role of NSAIDs in axSpA treatment, risks and benefits of this treatment, and current trends for individualized treatment.
引用
收藏
页码:601 / +
页数:12
相关论文
共 47 条
[31]   Comparison of two different dosages of celecoxib with diclofenac for the treatment of active ankylosing spondylitis: results of a 12-week randomised, double-blind, controlled study [J].
Sieper, J. ;
Klopsch, T. ;
Richter, M. ;
Kapelle, A. ;
Rudwaleit, M. ;
Schwank, S. ;
Regourd, E. ;
May, M. .
ANNALS OF THE RHEUMATIC DISEASES, 2008, 67 (03) :323-329
[32]  
Sieper J., 2012, ANN RHEUM DIS S3, V71, P247
[33]   Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis - The CLASS study: A randomized controlled trial [J].
Silverstein, FE ;
Faich, G ;
Goldstein, JL ;
Simon, LS ;
Pincus, T ;
Whelton, A ;
Makuch, R ;
Eisen, G ;
Agarwal, NM ;
Stenson, WF ;
Burr, AM ;
Zhao, WW ;
Kent, JD ;
Lefkowith, JB ;
Verburg, KM ;
Geis, GS .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2000, 284 (10) :1247-1255
[34]   Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention [J].
Solomon, SD ;
McMurray, JJV ;
Pfeffer, MA ;
Wittes, J ;
Fowler, R ;
Finn, P ;
Anderson, WF ;
Zauber, A ;
Hawk, E ;
Bertagnolli, M .
NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (11) :1071-1080
[35]   Benefits and risks of Ankylosing spondylitis treatment with nonsteroidal antiinflammatory drugs [J].
Song, I. H. ;
Poddubnyy, D. A. ;
Rudwaleit, M. ;
Sieper, J. .
ARTHRITIS AND RHEUMATISM, 2008, 58 (04) :929-938
[36]   Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis [J].
Trelle, Sven ;
Reichenbach, Stephan ;
Wandel, Simon ;
Hildebrand, Pius ;
Tschannen, Beatrice ;
Villiger, Peter M. ;
Egger, Matthias ;
Jueni, Peter .
BMJ-BRITISH MEDICAL JOURNAL, 2011, 342 :154
[37]   Radiographic progression of ankylosing spondylitis after up to two years of treatment with etanercept [J].
van der Heijde, D. ;
Landewe, R. ;
Einstein, S. ;
Ory, P. ;
Vosse, D. ;
Ni, L. ;
Lin, S. -L. ;
Tsuji, W. ;
Davis, J. C., Jr. .
ARTHRITIS AND RHEUMATISM, 2008, 58 (05) :1324-1331
[38]   Evaluation of the efficacy of etoricoxib in ankylosing spondylitis - Results of a fifty-two-week, randomized, controlled study [J].
van der Heijde, D ;
Baraf, HSB ;
Ramos-Remus, C ;
Calin, A ;
Weaver, AL ;
Schiff, M ;
James, M ;
Markind, JE ;
Reicin, AS ;
Melian, A ;
Dougados, M .
ARTHRITIS AND RHEUMATISM, 2005, 52 (04) :1205-1215
[39]   Radiographic Findings Following Two Years of Infliximab Therapy in Patients With Ankylosing Spondylitis [J].
van der Heijde, Desiree ;
Landewe, Robert ;
Baraliakos, Xenofon ;
Houben, Harry ;
van Tubergen, Astrid ;
Williamson, Paul ;
Xu, Weichun ;
Baker, Daniel ;
Goldstein, Neil ;
Braun, Juergen .
ARTHRITIS AND RHEUMATISM, 2008, 58 (10) :3063-3070
[40]   2010 Update of the international ASAS recommendations for the use of anti-TNF agents in patients with axial spondyloarthritis [J].
van der Heijde, Desiree ;
Sieper, Joachim ;
Maksymowych, Walter P. ;
Dougados, Maxime ;
Burgos-Vargas, Ruben ;
Landewe, Robert ;
Rudwaleit, Martin ;
Braun, Jurgen .
ANNALS OF THE RHEUMATIC DISEASES, 2011, 70 (06) :905-908