Oxidative stress and microcirculatory flow abnormalities in the ventricles during atrial fibrillation

被引：33

作者：

Goette, Andreas ^{[1
]}

Bukowska, Alicja ^{[2
]}

Lillig, Christopher H. ^{[3
]}

Lendeckel, Uwe ^{[3
]}

机构：

[1] St Vincenz Hosp Paderborn, Dept Cardiol & Intens Care Med, D-33098 Paderborn, Germany

[2] Univ Hosp Magdeburg, Working Grp Mol Electrophysiol, Magdeburg, Germany

[3] Ernst Moritz Arndt Univ Greifswald, Inst Med Biochem & Mol Biol, Greifswald, Germany

来源：

FRONTIERS IN PHYSIOLOGY | 2012年 / 3卷

关键词：

angiotensin; atrial fibrillation; microvascular flow; oxidative stress; NF-KAPPA-B; CONGESTIVE-HEART-FAILURE; II-INDUCED HYPERTENSION; CORONARY BLOOD-FLOW; GROWTH-FACTOR VEGF; NADPH OXIDASE; NAD(P)H OXIDASE; MITOCHONDRIAL DYSFUNCTION; CARDIAC-HYPERTROPHY; MYOCARDIAL-PERFUSION;

D O I：

10.3389/fphys.2012.00236

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Patients with atrial fibrillation (AF) often present with typical angina pectoris and mildly elevated levels of cardiac troponin (non-ST-segment elevation myocardial infarction) during an acute episode of AF. However, in a large proportion of these patients, significant coronary artery disease is excluded by coronary angiography, which suggests that AF itself influences myocardial blood flow. The present review summarizes the effect of AF on the occurrence of ventricular oxidative stress, redox-sensitive signaling pathways and gene expression, and microcirculatory flow abnormalities in the left ventricle.

引用

页数：9

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