The pregnancy microbiome and preterm birth

被引：104

作者：

Bayar, Erna ^{[1
]}

Bennett, Phillip R. ^{[1
,2
]}

Chan, Denise ^{[1
]}

Sykes, Lynne ^{[1
,2
]}

MacIntyre, David A. ^{[1
,2
]}

机构：

[1] Imperial Coll London, Parturit Res Grp, Inst Reprod & Dev Biol, Imperial Coll, Du Cane Rd, London W12 0HS, England

[2] Imperial Coll London, March Dimes European Preterm Birth Res Ctr, London, England

来源：

SEMINARS IN IMMUNOPATHOLOGY | 2020年 / 42卷 / 04期

基金：

英国医学研究理事会;

关键词：

Preterm birth; Pregnancy; Vaginal microbiome; Lactobacillus; CERVICAL INTRAEPITHELIAL NEOPLASIA; BACTERIAL VAGINOSIS; VAGINAL MICROBIOME; INTRAAMNIOTIC INFECTION; CERVICOVAGINAL MICROBIOTA; CLINICAL-SIGNIFICANCE; PREMATURE RUPTURE; GUT MICROBIOTA; ORAL BACTERIA; RISK;

D O I：

10.1007/s00281-020-00817-w

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Preterm birth is a global health concern and continues to contribute to substantial neonatal morbidity and mortality despite advances in obstetric and neonatal care. The underlying aetiology is multi-factorial and remains incompletely understood. In this review, the complex interplay between the vaginal microbiome in pregnancy and its association with preterm birth is discussed in depth. Advances in the study of bacteriology and an improved understanding of the human microbiome have seen an improved awareness of the vaginal microbiota in both health and in disease.

引用

页码：487 / 499

页数：13

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