Metabolism of bifenthrin, β-cyfluthrin, λ-cyhalothrin, cyphenothrin and esfenvalerate by rat and human cytochrome P450 and carboxylesterase enzymes

被引:10
作者
Hedges, Laura [1 ]
Brown, Susan [1 ]
MacLeod, A. Kenneth [1 ]
Moreau, Marjory [2 ]
Yoon, Miyoung [2 ]
Creek, Moire R. [3 ]
Osimitz, Thomas G. [4 ]
Lake, Brian G. [5 ]
机构
[1] Concept Life Sci, 2 James Lindsay Pl, Dundee DD1 5JJ, Scotland
[2] ScitoVation LLC, Res Triangle Pk, NC USA
[3] Moire Creek Toxicol Consulting Serv, Lincoln, CA USA
[4] Sci Strategies LLC, Charlottesville, VA USA
[5] Univ Surrey, Fac Hlth & Med Sci, Surrey, England
关键词
Bifenthrin; carboxylesterase; beta-cyfluthrin; lambda-cyhalothrin; cyphenothrin; cytochrome P450; esfenvalerate; human pyrethroids; rat; IN-VITRO METABOLISM; VIVO PHARMACOKINETICS; HYDROLYTIC METABOLISM; TRANS-PERMETHRIN; DELTAMETHRIN; AGE; LIVER; PYRETHROIDS; PLASMA; NEUROTOXICITY;
D O I
10.1080/00498254.2020.1795745
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
1. The metabolism of bifenthrin (BIF), beta-cyfluthrin (CYFL), lambda-cyhalothrin (CYHA), cyphenothrin (CYPH) and esfenvalerate (ESF) was studied in liver microsomes, liver cytosol and plasma from male Sprague-Dawley rats aged 90, 21 and 15 days and from adult humans. Pyrethroid metabolism was also studied with some human expressed cytochrome P450 (CYP) and carboxylesterase (CES) enzymes. 2. All five pyrethroids were metabolised by adult (90 day old) rat hepatic microsomal CYP and CES enzymes and by cytosolic CES enzymes. The pyrethroids were also metabolised by human liver microsomes and cytosol. Some species differences were observed. 3. Pyrethroid metabolism by cytosolic CES enzymes contributes to the overall hepatic clearance of these compounds. 4. CYFL, CYHA, CYPH and ESF were metabolised by rat plasma CES enzymes, whereas none of the pyrethroids were metabolised by human plasma. 5. This study demonstrates that the ability of male rats to metabolise these pyrethroids by hepatic CYP and CES enzymes and plasma CES enzymes increases with age. In all instances, apparent intrinsic clearance values were lower in 15 than in 90 day old rats. 6. All pyrethroids were metabolised by some of the human expressed CYP enzymes studied and apart from BIF were also metabolised by CES enzymes.
引用
收藏
页码:1434 / 1442
页数:9
相关论文
共 50 条
[41]   Cytochrome P450 isoenzymes involved in rat liver microsomal metabolism of californine and protopine [J].
Paul, LD ;
Springer, D ;
Staack, RF ;
Kraemer, T ;
Maurer, HH .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2004, 485 (1-3) :69-79
[42]   Cytochrome P450 expression and activities in rat, rabbit and bovine tongue [J].
Yang, SP ;
Medling, T ;
Raner, GM .
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, 2003, 136 (04) :297-308
[43]   Dexamethasone transcriptionally increases the expression of the pregnane X receptor and synergistically enhances pyrethroid esfenvalerate in the induction of cytochrome P450 3A23 [J].
Shi, Deshi ;
Yang, Dongfang ;
Yan, Bingfang .
BIOCHEMICAL PHARMACOLOGY, 2010, 80 (08) :1274-1283
[44]   Prediction of seriniquinone-drug interactions by in vitro inhibition of human cytochrome P450 enzymes [J].
da Silva, Rodrigo Moreira ;
Carrao, Daniel Blascke ;
Habenschus, Maisa Daniela ;
Jimenez, Paula Christine ;
Lops, Norberto Peporine ;
Fenical, William ;
Costa-Lotufo, Leticia Vera ;
Moraes de Oliveira, Anderson Rodrigo .
TOXICOLOGY IN VITRO, 2020, 65
[45]   Characterization of intestinal and hepatic P450 enzymes in cynomolgus monkeys with typical substrates and inhibitors for human P450 enzymes [J].
Yoda, Noriaki ;
Emoto, Chie ;
Date, Shoichi ;
Kondo, Satoshi ;
Miyake, Masateru ;
Nakazato, Satoru ;
Umehara, Ken ;
Kashiyama, Eiji .
XENOBIOTICA, 2012, 42 (08) :719-730
[46]   In vitro effects of tacrolimus on human cytochrome P450 [J].
Lecointre, K ;
Furlan, V ;
Taburet, AM .
FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2002, 16 (06) :455-460
[47]   Characterization of human cytochrome P450 induction by pesticides [J].
Abass, Khaled ;
Lamsa, Virpi ;
Reponen, Petri ;
Kublbeck, Jenni ;
Honkakoski, Paavo ;
Mattila, Sampo ;
Pelkonen, Olavi ;
Hakkola, Jukka .
TOXICOLOGY, 2012, 294 (01) :17-26
[48]   Metabolic Activation of Gemfibrozil Mediated by Cytochrome P450 Enzymes and Sulfotransferases [J].
Zhao, Min ;
Shi, Junzu ;
Li, Wei ;
Guan, Chunjing ;
Sun, Chen ;
Peng, Ying ;
Zheng, Jiang .
CHEMICAL RESEARCH IN TOXICOLOGY, 2022, :1257-1266
[49]   Modulation of cytochrome P450 enzymes by organosulfur compounds from garlic [J].
Davenport, DM ;
Wargovich, MJ .
FOOD AND CHEMICAL TOXICOLOGY, 2005, 43 (12) :1753-1762
[50]   Cytochrome P450 destruction by quinones: Comparison of effects in rat and human liver microsomes [J].
Soucek, P .
CHEMICO-BIOLOGICAL INTERACTIONS, 1999, 121 (03) :223-236