Azole Preexposure Affects the Aspergillus fumigatus Population in Patients

被引：30

作者：

Alanio, Alexandre ^{[1
,2
]}

Cabaret, Odile ^{[2
]}

Sitterle, Emilie ^{[2
]}

Costa, Jean-Marc ^{[2
]}

Brisse, Sylvain

Cordonnier, Catherine ^{[3
,4
]}

Bretagne, Stephane ^{[1
,2
]}

机构：

[1] Inst Pasteur, Unite Mycol Mol, Paris, France

[2] APHP, Grp Hosp Albert Chenevier Henri Mondor, Lab Parasitol Mycol, Creteil, France

[3] APHP, Grp Hosp Albert Chenevier Henri Mondor, Dept Hematol, Creteil, France

[4] Univ Paris Est Creteil, Creteil, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2012年 / 56卷 / 09期

关键词：

INVASIVE ASPERGILLOSIS; MICROSATELLITE MARKERS; HEMATOLOGICAL MALIGNANCIES; LOW-PREVALENCE; FRENCH COHORT; CYP51A GENE; RESISTANCE; POSACONAZOLE; PROPHYLAXIS; FLUCONAZOLE;

D O I：

10.1128/AAC.05990-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The relationship between the azole preexposure of 86 patients and the genotype, azole susceptibility, and cyp51A polymorphisms of 110 corresponding Aspergillus fumigatus isolates was explored. Isolates carrying serial polymorphisms (F46Y and M172V with or without N248T with or without D255E with or without E427K) had higher itraconazole MICs (P = 0.04), although <2 mu g/ml using the EUCAST methodology, were associated with two genetic clusters (P < 0.001) and with voriconazole preexposure of patients (P = 0.016). Voriconazole preexposure influences the distribution of A. fumigatus isolates with selection of isolates carrying cyp51A polymorphisms and higher itraconazole MICs.

引用

页码：4948 / 4950

页数：3

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