Decellularized Hydrogels in Bone Tissue Engineering: A Topical Review

被引:29
作者
Pacifici, Andrea [1 ]
Laino, Luigi [2 ]
Gargari, Marco [3 ]
Guzzo, Federico [4 ]
Luz, Andrea Velandia [5 ]
Polimeni, Antonella [6 ]
Pacifici, Luciano [6 ]
机构
[1] Univ Roma La Sapienza, Dept Oral & Maxillofacial Sci, Rome, Italy
[2] Univ Campania Luigi Vanvitelli, Multidisciplinary Dept Surg & Dent Specialties, Rome, Italy
[3] Univ Roma Tor Vergata, Dept Clin Sci & Translat Med, Rome, Italy
[4] Osped San Pietro FBF, Dept Dent GB Orsenigo, Rome, Italy
[5] Univ Macerata, Inst Legal Med, AgEstimat Project, Macerata, Italy
[6] Sapienza Univ Rome, Dept Oral & Maxillofacial Sci, Rome, Italy
来源
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES | 2018年 / 15卷 / 05期
关键词
Extra Cellular Matrix; bone tissue engineering; Hydrogels; MESENCHYMAL STEM-CELLS; OPTICAL COHERENCE TOMOGRAPHY; EXTRACELLULAR-MATRIX MIMICS; THIN ELASTOMERIC MEMBRANE; DENTAL-PULP; CHONDROGENIC DIFFERENTIATION; CHONDROCYTE TRANSPLANTATION; MECHANICAL CHARACTERIZATION; BIOMEDICAL APPLICATIONS; VISCOELASTIC PROPERTIES;
D O I
10.7150/ijms.22789
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Nowadays, autograft and allograft techniques represent the main solution to improve bone repair. Unfortunately, autograft technique is expensive, invasive and subject to infections and hematoma, frequently affecting both donor sites and surgical sites. A recent advance in tissue engineering is the fabrication of cell-laden hydrogels with custom-made geometry, depending on the clinical case. The use of ECM (Extra-Cellular Matrix)-derived Hydrogels from bone tissue is the new opportunity to obtain good results in bone regeneration. Several micro-engineering techniques and approaches are available to fabricate different cell gradients and zonal structures in hydrogels design, in combination with the advancement in biomaterials selection. In this review, we analyse the stereolithografy, the Bio-patterning, the 3D bioprinting and 3D assembly, the Laser-Induced Forward Transfer Bioprinting (LIFT), the Micro-extrusion bioprinting, the promising Electrospinning technology, the Microfluidics and the Micromolding. Several mechanical properties are taken into account for bone regeneration scaffolds. However, each typology of scaffold presents some advantages and some concerns. The research on biomaterials is the most promising for bone tissue engineering: the new biomimetic materials will allow us to obtain optimal results in the next clinical application of basic research.
引用
收藏
页码:492 / 497
页数:6
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