Genetics of Type 2 Diabetes in East Asian Populations

被引：53

作者：

Cho, Yoon Shin ^{[1
]}

Lee, Jong-Young ^{[2
]}

Park, Kyong Soo ^{[3
]}

Nho, Chu Won ^{[4
]}

机构：

[1] Hallym Univ, Dept Biomed Sci, Gangwon Do 200702, Chuncheon, South Korea

[2] Natl Inst Hlth, Ctr Genome Sci, Chungcheongbuk Do 363951, Cheongwon, South Korea

[3] Seoul Natl Univ, Dept Internal Med, Coll Med, Seoul 110744, South Korea

[4] Korea Inst Sci & Technol, Funct Food Ctr, Gangwon Do 210340, Gangneung, South Korea

来源：

CURRENT DIABETES REPORTS | 2012年 / 12卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

Type; 2; diabetes; Genome-wide association (GWA) study; Meta-analysis; Disease susceptibility locus; HapMap; Genetic variant; Ethnic populations; Genetics; GENOME-WIDE ASSOCIATION; PROTEIN-TYROSINE-PHOSPHATASE; IONOTROPIC GLUTAMATE RECEPTORS; UBIQUITIN-PROTEASOME SYSTEM; LARGE-SCALE ASSOCIATION; SUSCEPTIBILITY LOCI; TCF7L2; POLYMORPHISMS; GLUCOSE-HOMEOSTASIS; FASTING GLUCOSE; COMMON VARIANTS;

D O I：

10.1007/s11892-012-0326-z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Because type 2 diabetes (T2D) is highly familial, there has been a concentrated effort to uncover the genetic basis of T2D worldwide over the last decade. In East Asians, T2D is experiencing a rapidly rising prevalence that is characterized by a relatively lower body mass index, as compared with that in Europeans. To date, at least 15 convincing T2D loci have been identified from large-scale genome-wide association studies and meta-analyses in East Asians. Many of these are likely responsible for pancreatic beta cell function, as indicated in studies from Europeans. Many T2D loci have been replicated across the ethnic groups. There are, however, substantial interethnic differences in frequency and effect size of these risk alleles. Despite accumulating genetic information on T2D, there are still limitations in our ability to explain the rapidly rising prevalence and lean phenotype of disease observed in East Asians, suggesting that more extensive work using diverse research strategies is needed in the future.

引用

页码：686 / 696

页数：11

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