Microglia-T cell conversations in brain cancer progression

被引：15

作者：

Mirzaei, Reza ^{[1
,2
]}

Yong, V. Wee ^{[1
,2
]}

机构：

[1] Univ Calgary, Dept Clin Neurosci, Calgary, AB, Canada

[2] Univ Calgary, Hotchkiss Brain Inst, Calgary, AB, Canada

来源：

TRENDS IN MOLECULAR MEDICINE | 2022年 / 28卷 / 11期

基金：

加拿大健康研究院;

关键词：

TUMOR-ASSOCIATED MACROPHAGES; ANTITUMOR IMMUNITY; REVEALS; HETEROGENEITY; POLARIZATION; LYMPHOCYTES; INHIBITION; MECHANISMS; EXPRESSION; EFFICACY;

D O I：

10.1016/j.molmed.2022.08.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The highly immunosuppressive and heterogeneous milieu of brain malignancies contributes to their dismal prognosis. Regardless of their cellular origin, brain tumors grow in an environment with various specialized organ-resident cells. Although homeostatic microglia contribute to a healthy brain, conversations between disease-associated microglia and T cells compromise their individual and collective capacity to curb malignant growth. We review the mechanisms of T cell-microglia interactions and discuss how their collaboration fosters heterogeneity and immunosuppression in brain cancers. Because of the impor-tance of microglia and T cells in the brain tumor microenvironment, it is crucial to understand their interactions to derive innovative therapeutics.

引用

页码：951 / 963

页数：13

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