Microglia-T cell conversations in brain cancer progression

被引:15
作者
Mirzaei, Reza [1 ,2 ]
Yong, V. Wee [1 ,2 ]
机构
[1] Univ Calgary, Dept Clin Neurosci, Calgary, AB, Canada
[2] Univ Calgary, Hotchkiss Brain Inst, Calgary, AB, Canada
基金
加拿大健康研究院;
关键词
TUMOR-ASSOCIATED MACROPHAGES; ANTITUMOR IMMUNITY; REVEALS; HETEROGENEITY; POLARIZATION; LYMPHOCYTES; INHIBITION; MECHANISMS; EXPRESSION; EFFICACY;
D O I
10.1016/j.molmed.2022.08.006
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The highly immunosuppressive and heterogeneous milieu of brain malignancies contributes to their dismal prognosis. Regardless of their cellular origin, brain tumors grow in an environment with various specialized organ-resident cells. Although homeostatic microglia contribute to a healthy brain, conversations between disease-associated microglia and T cells compromise their individual and collective capacity to curb malignant growth. We review the mechanisms of T cell-microglia interactions and discuss how their collaboration fosters heterogeneity and immunosuppression in brain cancers. Because of the impor-tance of microglia and T cells in the brain tumor microenvironment, it is crucial to understand their interactions to derive innovative therapeutics.
引用
收藏
页码:951 / 963
页数:13
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