Synthesis of dendritic stationary phases with surface-bonded L-phenylalanine derivate as chiral selector and their evaluation in HPLC resolution of racemic compounds

被引：9

作者：

Yin, Chuan-Qi ^{[1
]}

He, Bao-Jiang ^{[2
]}

Huang, Shao-Hua ^{[2
]}

Zhang, Jun-Yi ^{[2
]}

Bai, Zheng-Wu ^{[2
]}

Li, Zao-Ying ^{[1
]}

机构：

[1] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Hubei Province, Peoples R China

[2] Wuhan Inst Chem Technol, Coll Chem Engn & Pharm, Wuhan, Hubei Province, Peoples R China

来源：

CHIRALITY | 2008年 / 20卷 / 07期

关键词：

dendrimer; chiral stationary phase; enantioseparation; high-performance liquid chromatography;

D O I：

10.1002/chir.20555

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four dendrimers were synthesized on aminopropyl-modified silica gel using methyl acrylate and ethylene diamine as building blocks by divergent method. Four generations of chiral stationary phases (CSPs) were prepared by coupling of L-2-(p-toluenesulfonamido)-3-phenylpropionyl chloride to corresponding dendrimers. The derivatives prepared on silica gel were characterized by FT-IR, H-1 NMR, and elemental analysis. The selector loadings of these four generations of CSPs generally showed a decrease tendency with the increase of generation numbers of dendrimers. The enantioseparation properties of these CSPs were preliminarily investigated by high-performance liquid chromatography. The CSP derived from the three-generation dendrimer exhibited the best enantioseparation capability. Effects of the mobile phase composition and molecular structures of racemic mixtures on enantioseparation were further studied.

引用

页码：846 / 855

页数：10

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