Salvage Debridement, Antibiotics and Implant Retention ("DAIR") With Local Injection of a Selected Cocktail of Bacteriophages: Is It an Option for an Elderly Patient With Relapsing Staphylococcus aureus Prosthetic-Joint Infection?

被引：73
作者：
Ferry, Tristan [1 ,2 ,3 ,4 ]
Leboucher, Gilles [5 ]
Fevre, Cindy [6 ]
Herry, Yannick [2 ,4 ,7 ]
Conrad, Anne [1 ,2 ,3 ,4 ]
Josse, Jerome [2 ,3 ,4 ,8 ]
Batailler, Cecile [2 ,4 ,7 ]
Chidiac, Christian [1 ,2 ,3 ,4 ]
Medina, Mathieu [6 ]
Lustig, S. [7 ]
Laurent, Frederic [2 ,3 ,4 ,8 ]
Ferry, Tristan [1 ,2 ,3 ,4 ]
Valour, Florent
Perpoint, Thomas
Boibieux, Andre
Biron, Francois
Miailhes, Patrick
Ader, Florence
Becker, Agathe
Roux, Sandrine
Triffault-Fillit, Claire
Bosch, Alexie
Daoud, Fatiha
Lippman, Johanna
Braun, Evelyne
Lustig, Sebastien
Servien, Elvire
Gaillard, Romain
Schneider, Antoine
Gunst, Stanislas
Fessy, Michel-Henry
Besse, Jean-Luc
Viste, Anthony
Chaudier, Philippe
Courtin, Cyril
Louboutin, Lucie
Martres, Sebastien
Trouillet, Franck
Barrey, Cedric
Jouanneau, Emmanuel
Jacquesson, Timothee
Mojallal, Ali
Boucher, Fabien
Shipkov, Hristo
Chateau, Joseph
Aubrun, Frederic
Dziadzko, Mikhail
Macabeo, Caroline
Beraud, Laeticia
Kolenda, Camille
机构：
[1] Hosp Civils Lyon, Hop Croix Rousse, Serv Malad Infect, Lyon, France
[2] Univ Claude Bernard Lyon 1, Villeurbanne, France
[3] Ctr Int Rech Infectiol, Lyon, France
[4] Hosp Civils Lyon, Ctr Interreg Reference Infect Osteoarticulaires C, Lyon, France
[5] Hosp Civils Lyon, Hop Croix Rousse, Pharm, Lyon, France
[6] Pherecydes Pharma, Romainville, France
[7] Hosp Civils Lyon, Hop Croix Rousse, Serv Chirurg Orthoped, Lyon, France
[8] Hosp Civils Lyon, Hop Croix Rousse, Inst Agents Infect, Lab Bacteriol, Lyon, France
来源：
OPEN FORUM INFECTIOUS DISEASES | 2018年 / 5卷 / 11期
关键词：
bacteriophage; DAIR; prosthetic-joint infection; S; aureus; suppressive therapy; MULTICENTER;
D O I：
10.1093/ofid/ofy269
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Local injection of a bacteriophages mix during debridement, antibiotics and implant retention ("DAIR") was performed to treat a relapsing Staphylococcus aureus chronic prosthetic joint infection (PJI). This salvage treatment was safe and associated with a clinical success. Scientific evaluation of the potential clinical benefit of bacteriophages as antibiofilm treatment in PJI is now feasible and required.
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