Dual-Frequency Calcium-Responsive MRI Agents

被引：43

作者：

Kadjane, Pascal ^{[1
]}

Platas-Iglesias, Carlos ^{[2
]}

Boehm-Sturm, Philipp ^{[3
]}

Truffault, Vincent ^{[4
]}

Hagberg, Gisela E. ^{[1
]}

Hoehn, Mathias ^{[3
]}

Logothetis, Nikos K. ^{[1
,5
]}

Angelovski, Goran ^{[6
]}

机构：

[1] Max Planck Inst Biol Cybernet, Dept Physiol Cognit Proc, D-72076 Tubingen, Germany

[2] Univ A Coruna, Dept Quim Fundamental, La Coruna 15008, Spain

[3] Max Planck Inst Neurol Res, In Vivo NMR Lab, D-50931 Cologne, Germany

[4] Max Planck Inst Dev Biol, Dept Biochem, D-72076 Tubingen, Germany

[5] Univ Manchester, Dept Imaging Sci & Biomed Engn, Manchester M13 9PT, Lancs, England

[6] Max Planck Inst Biol Cybernet, MR Neuroimaging Agents Grp, D-72076 Tubingen, Germany

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2014年 / 20卷 / 24期

关键词：

calcium; fluorine; imaging agents; magnetic resonance imaging; MAGNETIC-RESONANCE; CONTRAST AGENTS; LANTHANIDE(III) COMPLEXES; F-19; MRI; METAL-IONS; LIGANDS; SHIFTS; DOTA; SPECTROSCOPY; DESIGN;

D O I：

10.1002/chem.201400159

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Responsive or smart magnetic resonance imaging (MRI) contrast agents are molecular sensors that alter the MRI signal upon changes in a particular parameter in their microenvironment. Consequently, they could be exploited for visualization of various biochemical events that take place at molecular and cellular levels. In this study, a set of dual-frequency calcium-responsive MRI agents are reported. These are paramagnetic, fluorine-containing complexes that produce remarkably high MRI signal changes at the H-1 and F-19 frequencies at varying Ca2+ concentrations. The nature of the processes triggered by Ca2+ was revealed, allowing a better understanding of these complex systems and their further improvement. The findings indicate that these double-frequency tracers hold great promise for development of novel functional MRI methods.

引用

页码：7351 / 7362

页数：12

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