An Improved Synthesis of Nomegestrol Acetate

被引：9
作者：
Lu, He-Lin [1 ]
Wu, Zong-Wen [1 ]
Song, Shu-Yong [1 ]
Liao, Xiao-Dan [2 ]
Zhu, Yan [3 ]
Huang, Yun-Sheng [1 ]
机构：
[1] Guangdong Med Coll Sch Pharm, Dongguan 523808, Peoples R China
[2] Minist Tradit Chinese Med, Key Lab South China Essential Oil, Zhanjiang 524018, Peoples R China
[3] Shanghai Inst Planned Parenthood Res, Dept Reprod Pharmacol, Shanghai 200032, Peoples R China
来源：
ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2014年 / 18卷 / 03期
关键词：
C-13; NMR-SPECTRA; ORAL-CONTRACEPTIVES; TOTAL ASSIGNMENT; 17-BETA-ESTRADIOL; PROFILE; ETHINYLESTRADIOL; TOLERABILITY; PHARMACOLOGY; EFFICACY; REGIMEN;
D O I：
10.1021/op4003533
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Oral contraceptives (OCs) are synthetic steroids, or progestins, which are structurally related to testosterone or to progesterone. Many progestins have been synthesized and approved for OCs, hormonal replacement therapy (HRT), or the treatment of some gynecological disorders. Nomegestrol acetate (NOMAc) is a newly approved OC and has gained rapid acceptance in many countries for OC or HRT. The synthesis of NOMAc remains challenging and costly. We have developed a novel and improved procedure for the synthesis of NOMAc with a total of 11 steps and an overall good yield without the use of hazardous reagents. © 2014 American Chemical Society.
引用
收藏
页码：431 / 436
页数：6
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